thioguanine

(redirected from 6-thioguanine)
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Words related to thioguanine

an antineoplastic drug used to treat acute leukemias

References in periodicals archive ?
6-thioguanine was not tested because it is a chemotherapy drug with side effects that make it unsuitable as a potential stroke treatment.
Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.
Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease.
Simultaneous determination of 6-thioguanine and methyl 6mercaptopurine nucleotides of azathioprine in red blood cells by HPLC.
determining the level of 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder, wherein the level of 6-thioguanine in said subject, having said immune-mediated gastrointestinal disorder, wherein the level of 6-thioguanine less than about 230 pmol per 8x108 red blood cells indicates a need to increase the amount of said drug subsequently administered to said subject and wherein the level of 6-thioguanine greater than about 400 pmol per 8x 108 red blood cells indicates a need to decrease the amount of said drug susceptibility administered to said subject.
a) administering a drug providing 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder; and
13 Although its exact mechanism of action is not known, the major immunosuppressive effect is thought to result from blocking of DNA replication due to incorporation of the azathioprine metabolite 6-thioguanine nucleotide.
A more reproducible approach is to measure the metabolites 6-thioguanine (6-TGN) and 6 methylmer-captopurine (6-MMP).
Alternative systemic agents sometimes used for recalcitrant psoriasis management include hydroxyurea, sulfasalazine, azathioprine, mycophenolate mofetil, fumaric acid esters, 6-thioguanine and leflunomide.
Wiernik kindly responded: "I do not know of any five year or longer survivors of acute granulocytic [myelocytic] leukemia treated only with cytosine arabinoside and 6-thioguanine .
Objective: The aim of this study is to assess the relationship between TPMT activity and 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine ribonucleotide (6-MMPN) levels in patients with 11313 in clinical practice.
Azathioprine is converted to 6-mercaptopurine, which can be metabolized by xanthine oxidase to oxidized metabolites, by hypoxanthine-guanine phosphoribosyl transferase (HPRT) to 6-thioguanine nucleotides, or by thiopurine methyl transferase (TPMT) to 6-methylmercaptopurine (Fig.
2005) as well as racial differences in the genetic polymorphism of thiopurine S-methyltransferase (TPMT), a cystosolic enzyme that catalyzes the S-methylation of aromatic and hetercyclic sulfhydryl compounds, including 6-mercaptopurine, 6-thioguanine, and azathioprine (Hon, Fessing, Pui, Relling, Krynetski, & Evans 1999; Collie-Duguid et al.
In regard to drug resistance, MRP4 has been shown to efflux various chemotherapeutic agents, including topotecan, an anticancer agent, and 6-mercaptopurine and 6-thioguanine, two anticancer purine analogs.