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Words related to thioguanine

an antineoplastic drug used to treat acute leukemias

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References in periodicals archive ?
6-thioguanine was not tested because it is a chemotherapy drug with side effects that make it unsuitable as a potential stroke treatment.
Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.
Czul et al., "Concentrations of 6-thioguanine nucleotide correlate with trough levels of infliximab in patients with inflammatory bowel disease on combination therapy," Clinical Gastroenterology and Hepatology, vol.
Kumar, "Development of imprinted polyneutral red/electrochemically reduced graphene oxide composite for ultra-trace sensing of 6-thioguanine," Carbon, vol.
Generally, recommended therapies for UC patients include anti-inflammatory drugs (corticosteroids, prednisolone, aminosalicylic acid, and sulfasalazine), immunosuppressants (thiopurines, azathioprine, 6-mercaptopurine, and 6-thioguanine), and antibiotics (metronidazole and ciprofloxacin) [3-5].
Through their metabolite 6-thioguanine, the thiopurines azathioprine and 6-mercaptopurine can inhibit RAC-1 and the efficacy of anti-apoptotic factors in lymphocytes [64].
Schiestl, Noriyuki Kasahara Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow.
Two months later, when the transaminases were within the normal range, he received 6-thioguanine (6-TG) 25 mg a day, that was progressively increased to 80 mg a day.
Bioisosteric replacement of carbonyl oxygen in guanine (pyridine-imidazole ring system), a nitrogenous base by S gives 6-thioguanine (potent anti-cancer antimetabolite).
Lu, "Study on the interaction of 6-thioguanine with bovine serum albumin by spectroscopic techniques," Journal of Molecular Structure, vol.
6-Mercaptopurine and 6-thioguanine have been found in 1950s [1, 2].
Intraerythrocyte concentrations of 6-thioguanine nucleotides (6TGNs) were low (132 pmol/8 x 108 erythrocytes; therapeutic interval, 230-400 pmol/8 x [10.sup.8] erythrocytes), and 6-methylmercaptopurine ribonucleotides (6-MMPRs) were very high (11 666 pmol/8 x [10.sup.8] erythrocytes; therapeutic interval, <5800 pmol/8 x [10.sup.8] erythrocytes).
Wang et al., "6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation ofDNMT," Cancer Research, vol.