It is likely that exposure to corticosteroids, 6-mercaptopurine
, and subsequently infliximab increased the patient's immunosuppression and susceptibility to infection.
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
Drugs that interfere with niacin or tryptophan metabolism, such as isoniazid, pyrazinamide, 6-mercaptopurine
, 5-flurouracil, phenytoin, azathioprine, chloramphenicol, and ethionamide can also cause pellagra-like symptoms.
Toxicity of low dose azathioprine and 6-mercaptopurine
in rat hepatocytes.
Hepatotoxicity can occur with either of the two thiopurine analogs in use for IBD treatment, azathioprine (AZA) and 6-mercaptopurine
(6-MP), and varies in severity, timing, and clinical presentation.
The study also was unique in that patients were permitted to continue taking concomitant medications such as azathioprine, 6-mercaptopurine
, methotrexate, aminosalicylates, antibiotics, prednisone, or budesonide.
At 12 hours after admission, her blood methotrexate and 6-mercaptopurine
concentrations were 0.
These drugs, 6-mercaptopurine
(Purinethol), azathioprine (Imuran) and methotrexate (Folex PFS, Rheumatrex), suppress the immune system and enable you to be weaned off corticosteroids.
Azathioprine (AZA) and 6-mercaptopurine
(6-MP) are thiopurines that are purine antimetabolites.
1) Other causes include hypertriglyceridemia, infection, hypercalcemia, and medications such as azathioprine, 6-mercaptopurine
, trimethoprim sulfamethoxazole, and furosemide.
Azathioprine, a derivative of 6-mercaptopurine
, exhibits an impressive immunosuppressive effects and has been successfully used in rheumatoid arthritis, autoimmune bullous disorders, renal transplant patients and other autoimmune diseases.
Maintenance: Patients who achieved a complete response after consolidation treatment should continue on maintenance of one to two years of ATRA, which may be combined with 6-mercaptopurine
During maintenance therapy with 6-mercaptopurine
and Methotrexate she developed bicytopenia (macrocytic anemia and thrombocytopenia) one year after the diagnosis of the malignant lymphoma.
Traditionally these drugs (such as infliximab and adalimumab) have been used in cases refractory to standard treatment with corticosteroids and immunomodulators (such as azathiorine, 6-mercaptopurine
First-line therapy consisted of standard-dose cytarabine combined with an anthracycline [+ or -] 6-mercaptopurine