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Words related to thioguanine

an antineoplastic drug used to treat acute leukemias

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4 mol/L NaOH and 2 mol/L Tris base, 6-TG and 6-MMP derivative were extracted with 0.
A chromatogram of blank erythrocytes vs erythrocytes supplemented with 6-TG and 6-MMP and subjected to the sample treatment procedure is presented in Fig.
The conversion of 6-TG and 6-MMP nucleoside mono-,di-,and triphosphates to 6-TG and 6-MMP derivative was complete after a 60-min acid hydrolysis at 100[degrees]C (Fig.
Ion suppression experiments revealed that the biological matrix affected 6-TG (final concentration, 2.
In a second set of experiments, we investigated the effect of several DTT concentrations (2, 5, 10, 25, and 60 mmol/L) on 6-TG recovery with both methods, using pooled erythrocytes from patients on azathiprine therapy.
Our observed extraction efficiency for 6-TG with the Lennard procedure was ~40% compared with the 64% reported by Lennard (21).
For the Dervieux-Boulieu method (23), increasing the DTT concentrations from 2 to 60 mmol/L increased the recovery of 6-TG (Fig.
Previously we reported that the recoveries of 6-thiopurines like 6-TG were greatly influenced by the addition of DTT during the sample treatment procedure [10].
Concentration Concentration added, found, [micro] mol/L [micro] mol/L Compound packed cells packed cells CV, % Intraassay (n = 5) 6-TG 0.