There are some possible explanations for no more efficacy in the 5-ASA + AZA/6-MP group than in the AZA/ 6-MP
Allopurinol was first used to shift the metabolism of thiopurine compounds from 6-MMP to 6-TGN in poor responders to AZA or 6-MP
Afterward, the patient remained on 6-MP
therapy at the decreased dose of 50 mg/day, and aminotransferase levels normalized 1 month after the biopsy.
When compared with the group of healthy women who did not have IBD, the risk of congenital malformations was increased by about 45% among women with IBD who were treated with azathioprine or 6-MP
. But when the women on azathioprine or 6-MP
were compared with women with IBD who were not on one of the purines, there was no increased risk in malformation - which indicates that it is not prenatal exposure to azathioprine or 6-MP
but the condition itself that may increase the risk of malformations to some extent.
Conclusions: Higher TPMT activity is associated with lower 6-TGN levels and higher 6-MMPN levels in patients with IBD who were treated with AZA or 6-MP
in clinical practice.
An analysis predicted that 43% of all patients would survive without colectomies, but that significantly more patients who also received 6-MP
or azathioprine would survive without colectomy after 12 years than those who received cyclosporine alone (54% vs.
Markowitz published the results of an 18-month study in children with Crohn's disease comparing induction therapy with 6-MP
and prednisone vs.
The recommended doses that are used in children with UC are lower than those used in the transplant population (AZA = 1.5-2 mg/kg/day, 6-MP
= 1-1.5 mg/kg/day).
Azathioprine and 6-MP
may cause nausea, a decrease in white blood cells (leukopenia), and inflammation of the pancreas (pancreatitis).
The potential leukemogenic drugs that this patient received were anthracycline, 6-MP
, and MTX.
Patients with a history of cancer of any type, definite dysplasia of the colon within the last 5 years, or clinically significant renal or hepatic disease were ineligible, as were pregnant or breast-feeding women, patients who were allergic to AZA or 6-MP
, and patients receiving allopurinol.
Present retrospectively examined the use of 6-mer-captopurine (6-MP
) in 155 IBD patients with 325 pregnancies and 233 live births.
As induction therapy, the received vincristine (V), adriamycin (A), l-asparaginase (L-ASP), prednisone (P), and intrathecal (IT) cytarabine/methotrexate (ARA-C/ MTX) achieving complete remission in consolidation was initiated with V, A, P, L-ASP, and 6-mercaptopurine (6-MP
If you went to school on the East Coast you use 6-MP
. Most of the rest of the world uses azathioprine.
Thiopurine drugs, which include 6-mercaptopurine (6-MP
) (10) and azathioprine (aza), were introduced into clinical practice more than 50 years ago (1).