reductase

Clinical characterization and analysis of the SRD5A2 gene in six Korean patients with 5alpha-reductase type 2 deficiency.

Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism.

The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge.

Beginning shortly after conception, human skin produces 5alpha-reductase.

The association between polymorphisms in the CYP17 and 5alpha-reductase (SRD5A2) genes and serum androgen concentrations in men.

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11 beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

The rationale for inhibiting 5alpha-reductase isoenzymes in the prevention and treatment of prostate cancer.

We also know that testosterone is converted to dihydrotestosterone (DHT) by 5alpha-reductase isozymes, which is present in tissues such as the prostate.

Significantly, such chemoprevention strategies are also based on 5alpha-reductase inhibition thus reducing intraprostatic dihydrotestosterone levels.

Moreover, standard treatments for BPH symptoms, such as alpha blockers and 5alpha-reductase inhibitors, can cause sexual dysfunction.

Are Men on 5alpha-Reductase Inhibitors Appropriately Referred to Urology?

Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase II.

Liao Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.