activity in women with polycystic ovary syndrome.
New mutations, hotspots, and founder effects in Brazilian patients with steroid 5alpha-reductase
deficiency type 2.
Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase
The effects of 5alpha-reductase
inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge.
Beginning shortly after conception, human skin produces 5alpha-reductase
. Indeed, skin cells contain enzymes needed to produce every steroid hormone--and can contribute significantly to levels of circulating steroids.
Inhibition of 5alpha-reductase
in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone.
Molecular characterization of 6 unrelated Italian patients with 5alpha-reductase
type 2 deficiency.
Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11 beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase
The association between polymorphisms in the CYP17 and 5alpha-reductase
(SRD5A2) genes and serum androgen concentrations in men.
Significantly, such chemoprevention strategies are also based on 5alpha-reductase
inhibition thus reducing intraprostatic dihydrotestosterone levels.
We also know that testosterone is converted to dihydrotestosterone (DHT) by 5alpha-reductase
isozymes, which is present in tissues such as the prostate.
The rationale for inhibiting 5alpha-reductase
isoenzymes in the prevention and treatment of prostate cancer.
Moreover, standard treatments for BPH symptoms, such as alpha blockers and 5alpha-reductase
inhibitors, can cause sexual dysfunction.
Are Men on 5alpha-Reductase
Inhibitors Appropriately Referred to Urology?