Male patients on testosterone replacement therapy, those with a past medical or family history of prostate cancer, those currently or with a history of using 5a-reductase
Primary prevention of PCa has focused on chemoprevention, vitamin supplements (selenium, Vitamin E, and Vitamin C), and 5a-reductase
inhibitors (finasteride and dutasteride).
Compound Inhibitory to Rat Liver 5a-reductase
from Tropical Commercial Wood Species: Resveratrol Trimmer from Melapi (Shorea sp.
Alpha blockers and the 5a-reductase
inhibitors can also be given together, because some data suggest that using the drugs together is better than using either one alone.
After an appropriate informed consent-talk (Doc trained as a surgeon), she began a 5a-reductase
inhibitor, saw palmetto extract (SPE) 320 mg twice daily.
Washington, Jan 12 (ANI): Scientists have found that 5a-reductase
inhibitors (5a-RIs), while improving urinary symptoms in patients with benign prostatic hyperplasia (BPH) and possible hair loss prevention, produces significant adverse effects in some individuals including loss of libido, erectile dysfunction (ED), ejaculatory dysfunction and potential depression.
The biologically active androgen dihydrotestosterone is produced from testosterone in the prostate by the action of type 1 and type 2 steroid 5a-reductase
Possible explanations are a lack of 5a-reductase
activity or, more likely, deficient progesterone as substrate.
The ratio of 5a-THF:THF served to assess activity of the cortisol-catabolizing enzyme 5a-reductase
relative to 5[beta]-reductase.
In other words, testosterone is a target hormone itself as well as a circulating prohormone for several target tissues that possess the converting enzymes 5a-reductase