The mRNA of the gene, which encodes a receptor of 5-hydroxytryptamine
(serotonin), is expressed within vascular smooth muscle, endothelial cells, and cardiomyocytes, and plays a role in vasoconstriction and cellular proliferation .
Post-operative nausea and vomiting (PONV) is associated with general anaesthesia with a very high incidence of 80% especially in high-risk groups.1 The stimulation of the 5-hydroxytryptamine
type 3 (5-HT3) receptors in the gastrointestinal tract and central nervous system is said to be one leading factor in the genesis of emesis.2 That is why the drugs that act as antagonists to these receptors help in treating emesis.
Shiba et al., "Effect of 5-hydroxytryptamine
on gastrointestinal motility in conscious guinea-pigs," Neurogastroenterology & Motility, vol.
As shown in Figure 1(b), no single mode can provide satisfactory separation of the highly polar compounds present in LSW (such as 5-hydroxytryptamine
, peak 1) by conventional reverse-phase HPLC.
Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine
synthesis and tryptophan hydroxylase expression in dorsal raphe of rats.
Participation of 5-hydroxytryptamine
in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats.
Serotonin or 5-hydroxytryptamine
(5-HT) was chosen as the focus of this study for various reasons: first, because many behavioral disorders and the drugs used to treat them have been linked to serotonergic mechanisms [27, 38-40]; second, 5-HT projections and receptors have been described in multiple sites [14-16, 27], facilitating the search for the expression of related genes.
(5-HT) is a potent vasoactive amine that plays pivotal roles in insulin secretion [17-19], energy metabolism , mitochondrial biogenesis , the immune system [22, 23], and vascular inflammation [24-27].
Hammond, "Indicator dilution measurement of 5-hydroxytryptamine
clearance by human lung," Journal of Applied Physiology, vol.
However, clozapine has an effect over serotoninergic pathways that stimulate the [5-HT.sub.1A] receptor (5-hydroxytryptamine
) causing recirculation of gamma amino butyric acid in the nucleus accumbens leading to the inhibition of the dopaminergic neurons , related to the development of the disease.
Wightman, "Quantitative evaluation of 5-hydroxytryptamine
(serotonin) neuronal release and uptake: an investigation of extrasynaptic transmission," Journal of Neuroscience, vol.
Hundal, "Serotonin (5-hydroxytryptamine
), a novel regulator of glucose transport in rat skeletal muscle," Journal of Biological Chemistry, vol.
Colonic changes in UC are characterized by ulcerative lesions accompanied by a prominent infiltrate of immune cells as well as alteration in serotonin (5-hydroxytryptamine
; 5-HT) [9, 10].
found that the biogenic amines 5-hydroxytryptamine
(5-HT) and octopamine (OA) play a significant role in determining mating behavior in the lobster H.