reductase

(redirected from 5-alpha reductase)
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  • noun

Words related to reductase

an enzyme that catalyses the biochemical reduction of some specified substance

References in periodicals archive ?
Finasteride (Proscar[R], Propecia[R]) and dutasteride (Avodart[R]) are in a class of medications called 5-alpha reductase inhibitors because they block the effects of the enzyme and prevent the conversion of testosterone to DHT, but they don't reduce testosterone levels.
I wish to say that while I found the article intriguing in part, and scholarly, I firmly believe the same flaw is in this overview as in the article on men in Townsend a few months ago, advocating another potent drug, Clomid (clomiphene) that also isolated 5-alpha reductase as the primary, isolating factor that has to be managed reductively, sometimes with some very potent drugs.
Reasons for the current stagnation of progress include failure of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) to show preventive activity of selenium and vitamin E; the failure of a high-risk phase III study to show preventive activity of selenized yeast; the refusal of the Food and Drug Administration to approve finasteride for prostate cancer prevention; and uncertainty regarding the long-term effects of treatment with 5-alpha reductase inhibitors, according to Dr.
Another virtue to using 5-alpha reductase inhibitors (like Avodart[R] or Proscar[R]) is that in the presence of prostate cancer, PSA levels don't decrease as much after these drugs are initiated.
A novel missense mutation of 5-alpha reductase type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family.
The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase inhibitors like Proscar and Avodart, which lower levels of hormones produced by the prostate.
If changing medications is not an option, your doctor may prescribe a drug to help control your symptoms, such as an alpha-blocker like Flomax or 5-alpha reductase inhibitor like Avodart, which are used to treat problems caused by prostate enlargement.
For men with significant enlargement, drugs called 5-alpha reductase inhibitors (5-ARIs) are available to shrink the prostate.
Finasteride, a type II 5-alpha reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone, is used for the treatment of androgenic alopecia and has also been shown to decrease the incidence of prostate cancer.
comparison of Finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers.
Laboratory research has shown that mushroom extract can lower levels of 5-alpha reductase, an enzyme linked to male hormones involved in prostate cancer.
The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase.
Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor.
3-7) Its mechanism of action is believed to be derived from the stimulation of estrogenic and inhibition of progesterone receptors in prostatic tissues, (8) but it also exhibits antiestrogenic and antiandrogenic effects, inhibiting the actions of 5-alpha reductase enzyme and also the binding of dihydrotestosterone to androgen receptors.
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