deficiency: a 40-year retrospective review.
DHT is synthesized from testosterone by the enzyme 5-alpha reductase
I wish to say that while I found the article intriguing in part, and scholarly, I firmly believe the same flaw is in this overview as in the article on men in Townsend a few months ago, advocating another potent drug, Clomid (clomiphene) that also isolated 5-alpha reductase
as the primary, isolating factor that has to be managed reductively, sometimes with some very potent drugs.
Steroid 5-alpha reductase
type 2 (5[alpha]RD2) deficiency is a rare autosomal recessive disorder caused by mutations in the SRD5A2 gene.
Although medical treatment of BPH with alpha blockers and 5-alpha reductase
inhibitors may ameliorate the urinary symptoms, surgical intervention may be inevitable in some patients.
In one study, several other natural and synthetic polyphenolic compounds including anthrarobin were found to be effective inhibitor of type I 5-alpha reductase
which is involved in production of benign prostatic hyperplastic and prostatic cancer .
When testosterone is changed chemically by an enzyme in the skin (5-alpha reductase
), it becomes a more potent hormone known as Dihydrotestosterone (Dht).
Dihydrotestosterone, the active form of testosterone (Through action of 5-alpha reductase
) is responsible for prostatic hyperplasia and 5-alpha reductase
inhibitors provide base for medical treatment.
Gann suggested starting with compounds--especially dietary agents--that could inhibit 5-alpha reductase
However, the 5-alpha reductase
inhibitor trials provided proof of principle that the risk of a subset of prostate cancer can be reduced by drugs.
Although the molecular biological mechanisms influencing the etiology of BPH have not been elucidated; dihydrotestosterone (DHT), which is the more active from of testosterone and is converted from testosterone by 5-alpha reductase
, is known to play a central role in the prostate growth  and the oxidative stress-mediated mechanism is believed to also be associated with prostate cell hyperproliferation and tissue deformity [3,4].
(126) Avodart[R] and its less potent cousin Proscar[R] (finasteride) are 5ARIs (5-alpha reductase
Saw palmetto is scientifically proven to be an effective inhibitor of the enzyme (5-alpha reductase
), which produces dihydrotestostemne (DHT) within the hair follicle.
A novel missense mutation of 5-alpha reductase
type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family.
The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase
inhibitors like Proscar and Avodart, which lower levels of hormones produced by the prostate.