tamoxifen

(redirected from 4-hydroxytamoxifen)
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Synonyms for tamoxifen

an antagonist for estrogen that is used in the treatment of breast cancer

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References in periodicals archive ?
Reduced bioavailability of tamoxifen and its metabolite 4-hydroxytamoxifen after oral administration with biochanin A (an isoflavone) in rats.
A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast.
Zava, "Estrogen receptor-mediated and cytotoxic effects of the antiestrogens tamoxifen and 4-hydroxytamoxifen," Cancer Research, vol.
Abbreviations SpCas9: Cas9 from Streptococcus pyogenes SaCas9: Cas9 from Staphylococcus aureus PAM: Protospacer-adjacent motif NLS: Nuclear localization signal CRY2: Light-inducible heterodimerizing cryptochrome 2 CIB1: Calcium- and integrin-binding protein 1 4-HT: 4-Hydroxytamoxifen VPR: Chimeric activation domain composed of the activation domainsVP64, P65, and Rta pdDronpa: Engineered GFP that dimerizes in the dark LOV: Photomodulated dimerizing protein ER-LBD: Ligand-binding domain of the estrogen receptor.
Figure 2 shows that the ER compounds were inactive in the antagonist assays, Era_BLA_Antagonist and Era_LUC_BG1_Antagonist, except for 4-hydroxytamoxifen and raloxifene, which are known selective ER modulators (SERMs).
17[beta]-estradiol, 17[alpha]-estradiol, 4-hydroxytamoxifen, Raloxifene, genistein, LY294002, bovine serum albumin (BSA), normal goat serum, insulin, transferrin, hydrocortisone, fetuin, pancreatin, and trypsin were from Sigma (St.
SERM; selective estrogen receptor modulator such as tamoxifen (TAM) commonly used in premenopausal survivors Al: aromatase inhibitor such as anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara) used only in postmenopausal survivors to block the conversion of adrenal testosterone to estrogen SSRI: selective serotonin reuptake inhibitor Notes: Tamoxifen-treated patients carrying CYP2D6 variants that impaired formation of 4-hydroxytamoxifen, had more than double the risk of recurrence of breast cancer, shorter reiapse-free periods, and worse event-free survival rates compared with patients with functional CYP2D6.
In their study, the researchers used a drug called "4-hydroxytamoxifen"
It highlights the biotransformation of tamoxifen into primary and secondary metabolites with an emphasis on the clinically active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyltamoxifen (endoxifen).
One approach to regulate Cre activity utilizes a mutant estrogen hormone binding domain (ERTM) to keep Cre inactive unless the non-steroidal estrogen analog 4-hydroxytamoxifen (4OH-TM) is present (Hayashi and McMahon, 2002) (Figure 4A).
The LIF spectra of the cancer cell treated with 4-hydroxytamoxifen are also collected and compared with the standard LIF spectra of breast cancer cell lines to study the reaction of cell by chemical treatment.
ASCEND Therapeutics, Herndon, Va., has filed a patent application for both the pharmaceutical composition of TamoGel(tm) (4-hydroxytamoxifen gel) and the gel's use for the treatment of benign breast disease.
ASCEND Therapeutics (Herndon, VA) announced that it has filed a patent application for both the pharmaceutical composition of TamoGel (4-hydroxytamoxifen gel) and the gel's use for the treatment of benign breast disease.