tamoxifen

(redirected from 4-hydroxytamoxifen)
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  • noun

Synonyms for tamoxifen

an antagonist for estrogen that is used in the treatment of breast cancer

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References in periodicals archive ?
Compared with endoxifen, the steady-state concentrations of 4-hydroxytamoxifen are lower, ranging from 1.
TamoGel(tm)'s active ingredient, 4-hydroxytamoxifen, is the most active metabolite of the FDA-approved drug tamoxifen, a widely-prescribed adjuvant therapy for breast cancer.
TamoGel's active ingredient, 4-hydroxytamoxifen, is the most active metabolite of the FDA-approved drug tamoxifen, a widely-prescribed adjuvant therapy for breast cancer.
There is also "compelling evidence" that the drug's active metabolite in the body -- 4-hydroxytamoxifen -- stimulates the growth of human endometrial cancer cells grown in culture, notes Liam J.
ASCEND Therapeutics, a leading research and development company of pharmaceutical transdermal therapies for the treatment of chronic conditions, today announced that researchers presented findings regarding the company's 4-hydroxytamoxifen (4-OHT) gel during the 53rd Annual Clinical Meeting of the American College of Obstetricians and Gynecologists (ACOG) at the Moscone Center in San Francisco.
Dallas, TX, USA); and 4-hydroxytamoxifen (OHT; CAS number 68392-35-8, purity 99%) from Zeneca (Macclesfield, UK).
Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53 (-) normal human mammary epithelial cells by inducing mitochondrial depolarization.
Then, they introduced 4-hydroxytamoxifen to the mice, activating the telomerase in their cells.
Afimoxifene is 4-hydroxytamoxifen, a highly potent metabolite of tamoxifen, in a proprietary hydroalcoholic gel.
The use of the innovative EHG(TM) technology as a delivery vehicle for 4-hydroxytamoxifen has enabled the clinical development of this promising, but previously undeveloped molecule, now in Phase II trials.