Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin
in male offspring rats exposed throughout pregnancy and lactation.
Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
and related compounds.
Hypophagia-induced weight loss in mice, rats, and guinea pigs treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
disrupts B-cell lymphopoiesis and exacerbates autoimmune disease in 24-week-old SNF1 mice.
Based on in vivo evidence of toxicity, the World Health Organization (WHO) assigned each congener a toxic equivalency factor (TEF), a measure of relative potency compared with that of reference chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin
(Van den Berg et al.
(TODD), an environmental pollutant, mediates toxicity through the aryl hydrocarbon receptor (AhR), a soluble, ligandactivated transcription factor.
For example, traces of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) were identified in the fat of six workers contaminated during a 1953 chlorophenol explosion in West Germany.
(TCDD)] ligands, can dramatically impact host metabolism and immunity (Angrish et al.
(TCDD) is a potent environmental contaminant that elicits toxicity by activating the aryl hydrocarbon receptor.
Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) increased mortality after infection with Listeria monocytogenes (Sugita-Konishi et al.
The aryl hydrocarbon receptor (AhR) is a soluble receptor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), a potent and persistent environmental pollutant.
(TCDD) is a ubiquitous environmental pollutant and the most potent aryl hydrocarbon receptor (AHR) ligand.
(TCDD) is a widespread environmental contaminant and potent endocrine disruptor (Birnbaum and Tuomisto 2000; Zook and Rappe 1994).
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) is associated with hyperinsulinemia and insulin resistance.
Ahmed (2011) suggested that the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) on brain AChE were related to alterations in thyroid development.