Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin
and of nicotinamide as a corrective agent for this effect.
Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
causes accelerated terminal differentiation in fetal mouse skin.
induced alterations in protein phosphorylation in guinea pig adipose tissue.
(TCDD) alters pancreatic membrane tyrosine phosphorylation following acute treatment.
OBJECTIVES: We investigated the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) on acetylcholinesterase (AChE), a key enzyme in cholinergic neurotransmission.
The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin
Mortality rates among trichlorophenol workers with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
in the developing male Wistar(Han) rat.
Polychlorinated dibenzodioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) constitute a group of widespread and persistent organic pollutants with 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD, dioxin) being the most toxic member of this group (Birnbaum 1994b, 1995a, 1995b).
POPs include dioxins and furans--with 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) being the most potent of these and polychlorinated biphenyls (PCBs).
METHODS: Using human multipotent adipose-derived stem cells, we carried out large-scale gene expression analysis to identify the major pathways modified by 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), polychlorinated biphenyl (PCB) congener 126 (PCB-126), and PCB-153 and to evaluate their toxic effects.
PCBs are structurally related to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD, or "dioxin"), and depending on their particular chlorine substitution pattern, some congeners may produce health effects similar to TCDD (i.
Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
are associated with increased superoxide.
Resultsof a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin