and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity.
Blocking expression of AHR2 and ARNT1 in zebrafish larvae protects against cardiac toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
. Toxicol Sci 94(1):175--182, PMID: 16936225, https://doi.org/10.
Buckalew, "AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGF [alpha], TGF [beta] 1, TGF [beta] 2, and TGF [beta] 3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD)," Teratology, vol.
Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
and related compounds.
Source: Adapted from "Draft Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
(TCDD) and Related Compounds," Volume 3, Chapter 3, Table 3-56, U.S.
High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin
. Anal Chem 59:2000-2005.
Agent Orange, a mixture of two herbicides, contained the toxic contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
, which can impair neurotransmission, generate excitotoxic amino acids, and accelerate free radical formation in the nervous system.
The key that most effectively unlocks this receptor's toxic potential is 2,3,7,8-tetrachlorodibenzo-p-dioxin
The TEQ represents the toxicity of any combination of species in terms of an equally toxic concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin
, which is believed to be the most toxic congener.
The POP 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) is the most toxic congener of the dioxin family and is also one of the most potent activators of the aryl hydrocarbon receptor (AhR) (Barouki et al.
As a graduate student, she investigated mechanisms by which exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD or dioxin) suppresses the immune system.
Rodent studies suggest that the potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), is associated with delayed preputial separation (Bell et al.
The aryl hydrocarbon receptor (AhR) is a soluble, ligand-activated transcription factor that mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) and related chemicals.
) is the most toxic member of a class of 75 chlorinated compounds known as dioxins.
The importance of the AHR to human health is demonstrated in part by epidemiological studies based on the population in Seveso, Italy, that was accidentally exposed to the prototypical AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), where the risk for lymphatic and hematological cancers was found to be slightly elevated in adults (Consonni et al.