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Using a Saccharomyces cerevisiae system, Schultz and Sinks (2002) reported estrogenic gene activity of the hydroxylated metabolites of naphthalene such as 1-naphthol and 2-naphthol, but not of the parent compound.
Phenylphosphorodichloridate (PPDC), biphenylphosphorodichlondate, and naphthylphosphorodichloridate were prepared from phenol, 1-naphthol, and 4-phenylphenol, respectively, with phosphorusoxychloride using procedure reported elsewhere 
1-naphthyl phosphatase, 1-naphthol, ethylenediaminetetraacetic acid, bovine serum albumin (BSA), nitro blue tetrazolium and Tween 20 were obtained from Sigma Chemical Co.
Figure 2 presents the cumulative distributions of urinary 1-naphthol to 2-naphthol ratios in the CHAMACOS cohort and NHANES.
Human exposure to naphthalene is nearly universal; the recent National Health and Nutrition Examination Survey studies demonstrated detectable levels of 1-naphthol glucuronide in the urine of all 2,785 subjects tested (Li et al.
For example, 1-naphthol is a metabolite of both naphthalene (used as a moth repellent and also a polycyclic aromatic hydrocarbon from combustion processes) and carbaryl (Shealy et al.
Our results show that both inhalation exposure and smoking significantly contributed to urinary 1-naphthol levels.
In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans.
Urinary 1-naphthol and 1-pyrenol as indicators of exposure to coal tar products.
8]]naphthalene ([greater than or equal to] 98 atom% D), 1-naphthol ([greater than or equal to] 99%), 2-naphthol ([greater than or equal to] 99%), [[sup.
Both carbaryl and naphthalene are sources of the 1-naphthol metabolite.
42 for 1-naphthol, 3,5,6-trichloropyridinol, and 4-nitrophenol, respectively.
5 ND Carbamates Bendiocarb 5 97 49 ND Carbofuran 1 89 45 ND Carbofuranphenol (a) 1 0 0 -- 1-Naphthol (a) 20 42 21 ND Propoxur 1-2 7 3.
These chemicals and sex hormones were glucuronidated by members of a subfamily of UGTs named the 2B subfamily, and 1-naphthol was shown to be glucuronidated by the UGT1A subfamily (18).
This study measured four specific urinary metabolites: 1-naphthol (1-NAP), atrazine metcapturate (AM), malathion dicarboxylic acid (MDA), and 3,5,6-trichloro-2-pyridinol (TCPy).
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