Subsequently,1,3-diploar cycloaddition of azomethineylide 4 with acrylates 5 or 1,4-naphthoquinone
6 produces the final products (Scheme 1).
2005 1 1,4-Naphthoquinone
2 E 2 2-Tridecanone 42 J 3 6-methylnaphthoquinone 1 L 4 Methyl branched 2-tridecanone 8 M or N 5 2-Tetradecanone 9 M or N 6 6-Methyl-1,4-naphthalenediol 1 Not detected 7 2-Pentadecadienone 8 S 8 2-Pentadecenone 7 U 9 Unsaturated ketone a 3 ?
The report includes 1,4-naphthoquinone
description, covers its application areas and related patterns.
General procedure for preparing mono- (3a-g) and disubstituted 1,4-naphthoquinones
(4a-d, 4f-g) from 2,3-dichloro-1,4-naphthoquinone
Numerous therapeutic drugs, in particular antitumor compounds, are quinone-bearing molecules including anthracyclines (doxorubicin, mitoxanthrone, and daunarubicin), benzoquinones (mitomycin C, geldanamycin), orthonaphthoquinones like [beta]-lapachone, and several synthetic compounds which are currently under clinical trials using 1,4-naphthoquinone
as pharmacophore group [6-9].
Previous studies on the anticancer activities of this 1,4-naphthoquinone
derivative are mostly focused on its cytotoxic properties via the induction of apoptosis and necrosis (Ding et al.
Gas-phase atmospheric chemistry of 1- and 2-nitronaphthalene and 1,4-naphthoquinone
Fandy, Determination of Ag(I) with chemically modified carbon paste electrode based on 2,3- dicyano 1,4-naphthoquinone
Effects of quinone derivatives, such as 1,4-naphthoquinone
, on DNA polymerase inhibition and anti-inflammatory action.
is a potent inhibitor of human cancer cell growth and angiogenesis.
Antiplatelet and antithrombotic activities of CP201, a newly synthesized 1,4-naphthoquinone