BioDuro biology maintains an advanced in vivo oncology capability, including 18,000 sq ft AAALAC accredited vivarium, cell-derived xenograft
, patient-derived xenograft
, and syngeneic oncology models, with animal imaging and multi-color flow cytometry for immune cell analysis.
The research findings, which come as Sutro prepares to file an investigational new drug application to begin the clinical testing, show that STRO-001 eliminated tumors or significantly delayed tumor growth in diffuse large B-cell lymphoma and mantle cell lymphoma xenograft
models and prolonged survival in the disseminated Mino mantle cell lymphoma xenograft
model compared to tumor models treated with vehicle, which developed advanced disease with palpable neck and abdominal tumors.
Therefore, we tested the anti-tumour effect of MTE and gefitinib in resistant NSCLC xenograft
tumours with K-ras mutations or EGFR L858R/T790M mutation.
In our 2010 Nature article featured here, we described a next-generation sequencing-based whole-genome study to compare 4 related genomes from a single patient: a primary triple negative breast cancer, its counterpart xenograft
[or "patient-derived xenograft
" (PDX)], and a brain metastasis that occurred upon disease progression, all compared with the blood-derived normal DNA.
5, 7) However, germ cell anomalies, possibly due to DBP-related effects on Sertoli cells, have been observed in fetal rat and mouse testes as well as samples of fetal human testis xenografts
(testicular tissue implanted under the skin of mice).
MinerOssA X is a xenograft
alternative for predictable bone regeneration and complements our highly successful line of MinerOssA allografts.
Once the hyperacute rejection is overcome, another immunological obstacle to long-term xenograft
survival may be the human [CD8.
The company will officially launch the Sterling xenograft
line at the American Association of Orthopaedic Surgeons annual meeting in March.
The porcine xenograft
concept is not new; pig heart valves have been used for years.
And 18 years after Baby Fae survived three weeks with a transplanted baboon heart - eventually succumbing to a blood type incompatibility - scientists say the prospect of another groundbreaking xenograft
is alive and exciting.
A further requirement is that all recipients of xenotransplants must consent to an autopsy at death in order to study the effects of the xenograft
on the recipient's anatomy.
Alexion has numerous patent applications pending worldwide covering key aspects of xenograft
rejection, and expects to continue to file such innovative applications in the years to come.
An equally destructive immune response, known as delayed xenograft
rejection, can occur in the days after a transplant.
In this essay I would like to identify these irresistible themes of progress, not so much to argue against them as to make them evident so that our future collective deliberations on the ethics of xenograft
technologies, or any other step in medical progress, will be informed by attention to the seductions that may drown out dissension and cloud our better judgment.
It is similar to other triple-immunodeficient models in that it is capable of hosting xenograft
cells, tissue, and human immune system components, enabling researchers to further study tumor biology and immuno-oncology.