Distally, Wallerian degeneration
takes place, resulting in axonal degeneration.
The spinal cord up to C1 showed marked Wallerian degeneration
of the peripheral white matter from the median fissure, which extended along the ventral funiculus up to the most dorsal section of the lateral funiculus.
Emphasizing the therapeutic potential of post-injury AT treatment in spinal cord injuries, the investigation also strengthens the idea of long-term benefits that include reduction of secondary pathology through suppression of inflammation, Wallerian degeneration
, gliosis, and most importantly-neuronal apoptosis.
2) Following the trauma, the interruption in the continuity of a nerve results in wallerian degeneration
, characterized by the loss of axons in the proximal stump and retraction of axons in the distal segment.
occurred in the dorsal funiculus where the white discoloration was observed on gross examination.