29, the agency had accumulated 101 reports, including the 24 initial ones, of people who have taken fenfluramine or dexfenfluramine usually in combination with phentermine, and have experienced symptoms of valvular heart disease
Physicians who prescribe these medications should really evaluate their prescribing criteria and weigh the benefits of weight loss against the potential risks of valvular heart disease
and pulmonary hypertension,'' she said.
Unstable cardiovascular conditions include unstable coronary syndromes, decompensated cardiac failure, significant arrhythmias and severe valvular heart disease
Askari and Lincoff (cardiovascular medicine, Cleveland Clinic) compile 24 chapters that examine available antithrombotic regimens for interventions and treatment of diseases such as atrial fibrillation, cardiomyopathy, valvular heart disease
, and heparin-induced thrombocytopenia.
Other comorbidities, including obesity, valvular heart disease
, diabetes, and chronic pulmonary disease, were not significantly associated with an increased risk.
The fourth case occurred in a 37-year-old white woman from Baltimore, who had a history of intravenous drag use, chronic deep vein thrombosis, and valvular heart disease
Valvular heart disease
associated with the diet drugs dexfenfluramine and phentermine has been shown not to be progressive and does not require serial echocardiography to detect additional valve damage years after discontinuing the agents, according to a series of reports unveiled at an echocardiography meeting in Washington.
Patients, however, who have atrial fibrillation in the setting of hypertension, an overactive thyroid, valvular heart disease
or coronary artery disease, do require anticoagulation to prevent the occurrence of a stroke.
Patients should not take BELVIQ in combination with drugs that have been associated with valvular heart disease
2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease
They discuss cholesterol and atherosclerosis; risk factors for and the prevention of coronary heart disease, including diet, exercise, smoking, high cholesterol, high blood pressure, and obesity, as well as diagnostic and treatment procedures; forms and treatment of atherosclerotic vascular disease, including angina, heart attack, peripheral artery disease, and stroke; and arrhythmias, heart failure, and valvular heart disease
and dietary and lifestyle recommendations, medication and surgery, and new implantable devices.
Patients with hypertension, diabetes mellitus, atrial fibrillation, atrioventricular conduction anomalies, valvular heart disease
other than MR, history of ischemic heart disease or revascularization, history of valvular surgery, acute coronary syndromes, LV systolic dysfunction, segmental wall motion abnormalities, pericardial disease, other causes of MR (ischemic, degenerative or myxomatous), as well as patients whose LA had an inadequate imaging quality, were excluded from the study.
Of note, they share this mechanistic pathway with fenfluramine and dexfenfluramine, antiobesity drugs withdrawn from the market in 1997 due to reports of valvular heart disease
and pulmonary hypertension in patients taking the so-called "fen-phen" combination.
Based on indication the market is segmented as known/suspected CAD, valvular heart disease
, congenital heart disease, and congenital heart failure.
ESC Working Group on Valvular Heart Disease
Position Paper--heart valve clinics: organization, structure, and experiences.