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  • noun

Words related to transgene

an exogenous gene introduced into the genome of another organism

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Regardless of how delivery is achieved, the influx of transgene carrying virus-like particles to the target region results in the "infection" of a significant proportion of host cells.
BioInvent International AB (STO: BINV), a business focused on the discovery and development of novel and first-in-class immuno-regulatory antibodies to treat cancer, and Transgene (Paris: TNG), a company that designs and develops viral-based immunotherapies, announced on Wednesday the entering into a collaboration to treat solid tumours.
Under the terms of the agreement, Transgene will develop novel anticancer oncolytic virus drugs using its proprietary Vaccinia virus (TK-, RR-) strain, and its expertise in molecular engineering and translational research.
The aim of the collaboration between the scientific teams at both Servier and Transgene is to evaluate and select innovative vectorization methods based on Transgene's viral vector collection, which may be applied to the engineering of CAR-T cell therapies.
However, there are limitations to these methods: transgene leakiness when expression is turned off and secondary effects from the inducers [6,7].
Based on the results obtained with TG4010 in a large Phase 2b trial (TIME trial) in combination with chemotherapy, we are hopeful that this triple combination regimen could provide a treatment option for patients with advanced NSCLC, commented Philippe Archinard, Chairman and CEO Transgene.
If the worms were kept at 20 degrees Celsius (68 degrees Fahrenheit), the array of transgenes was less active, creating only a small amount of fluorescent protein, but when they were exposed to a warmer temperature of 25 degrees Celsius (77 degrees Fahrenheit), the activity of the transgenes was significantly increased.
The sheep were fed on GM insect-resistant maize grains followed by amplification of transgene through PCR assay.
In parallel to this transaction, Transgene and ABL Europe have signed a three-year agreement under which Transgene has secured the production of the necessary clinical lots for its clinical development plan.
This report provides comprehensive information on the current therapeutic developmental pipeline of Transgene SA's, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Transgenic are organisms into which transgene has been artificially introduced and the transgene stably integrated into their genomes [1].
Global Markets Direct's, 'Transgene Biotek Limited - Product Pipeline Review - 2015', provides an overview of the Transgene Biotek Limited's pharmaceutical research and development focus.
They are unique in the marketplace as they offer superior germplasm (living tissue from which new plants can grow), combined with a Yield and Stress transgene (DNA of one organism that has been transferred to another organism), bringing more technical benefits to the production field.
A copy of the management presentation will be accessible by visiting the Transgene website www.
Surveying current research in plant biotechnology, the 16 papers cover transformations mediated by Agrobacterium; other transformation technologies; vectors, promoters, and other tools for plant transformations; transgene integration, stability, methylation, silencing; and selection systems, marker-free transformation.