gout, patients develop a chronic debilitating arthritis with loss of function.
We report the first case of bilateral knee arthroplasty in a patient with both articular and subcutaneous tophaceous
deposits account for the bone erosions seen in gouty arthritis.
Prophylactic therapy is indicated when frequent attacks occur and when complications or tophaceous
gout are present.
The differential diagnosis at this point was possible tophaceous
involvement of the synovium in a patient with known gout.
It becomes clear that this patient is at high risk for septic arthritis because of his history of tophaceous
Our patient presented with tophaceous
gout of the spine in the absence of peripheral tophi and without a previous history of gouty arthritis.
Savient's Krystexxa (pegloticase) launched in the United States in February 2011 for the small population of patients with chronic tophaceous
gout but, to date, has failed to earn substantial sales, due to its high price and tendency to induce neutralizing antibodies which limit the duration of effect.
Gout has two clinical presentations affecting the musculoskeletal system--acute arthritis and chronic tophaceous
1 List of Tables Table 1: Risk Factors and Comorbidities for Gout 26 Table 2: Summary of Reported Incidence and Prevalence of Gout in the 6MM* 28 Table 3: American College of Rheumatology Criteria for the Clinical Diagnosis of Gout 31 Table 4: Sources of Gout Incidence Data in 6MM 32 Table 5: Sources of Gout Prevalence Data in 6MM 33 Table 6: Sources of Gout Flare and Tophaceous
Gout Data in 6MM 34 Table 7: 6MM, Sources Not Used in the Epidemiological Analysis of Gout 39 Table 8: 6MM, Diagnosed Incident Cases of Gout, Both Sexes, Ages?
When I see patients with tophaceous
gout, my target is never 6.
For patients on dual oral therapy at maximum acceptable doses who were still having frequent flares or those with unresolving chronic tophaceous
arthropathy, the TFP recommended pegloticase.
deposits, grayish discoloration, and hallux valgus deformity were noted on the great toe on both sides.
Studies on the interaction of rheumatoid factor with monosodium urate crystals and case report of coexistent tophaceous
gout and rheumatoid arthritis.
For patients with tophaceous
deposits caused by gout, treatment with currently available therapies takes a period of years to achieve tophus resolution," said Herbert S.