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Related to tolbutamide: acarbose, metformin
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Synonyms for tolbutamide

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However, tolbutamide is exclusively hepatically metabolized and may be used in patients with CKD(American Society of Health-Systems Pharmacists, 2011c).
These results are comparable with the dose of Tolbutamide treated group also showed a significant fall of 26 per cent (P<0.
5) In a study using tolbutamide 500 mg as a CYP2C9 probe substrate, healthy subjects were CYP2C9*1 homozygotes, CYP2C9*1*2 heterozygotes, and CYP2C9*1*3 heterozygotes.
05), which is comparable to that of the standard drug tolbutamide (20 mg/kg b.
Forty healthy mice were divided into 4 groups and administered orally for 7 days either saline solution, tolbutamide (positive control), 200 mg/kg CSP-1 or 400 mg/kg CSP-1.
The sulfonylureas were kindly supplied by the following manufacturers: glibenclamide, glimepiride, and tolbutamide by Aventis (Paris, France); glipizide and chlorpropamide by Pfizer (Paris, France); gliclazide and carbutamide by Servier (Neuilly-sur-Seine, France); glibornuride by CSP (Cournon, France); and glisoxepide by Bayer (Puteaux, France).
2002) analyzed tolbutamide, a drug cleared primarily via CYP2C.
Table 1 Statin metabolism and potential drug interactions Route of Drugs that inhibit Statin Metabolism metabolism Lovastatin CYP450 3A4 Erythromycin Simvastatin CYP450 3A4 Itraconazole Atorvastatin CYP450 3A4 Diltiazem Cerivastatin CYP450 3A4 Cyclosporin Pravastatin none Fluvastatin CYP450 2C9 Phenytoin, diclofenac, tolbutamide Table 2 Causes of elevated serum CPK Common causes Alcohol intoxication Muscle trauma Hypothyroidism Hyperthyroidism Seizure Drug overdose Uncommon causes Hypokalemia Dermatomyositis Polymyositis Hypophosphatemia Hypomagnesemia Hyponaterimia Hyperparathyroidism Rare causes Sepsis Spider bites Snake bites
Oral antidiabetes drugs got a bad name during pregnancy mainly from early studies on the first-generation sulfonylureas tolbutamide and chlorpropamide.
The study, presented here at the annual meeting of the American Diabetes Association, suggests that repaglinide stimulates insulin secretion by binding to a different receptor location compared to nateglinide and tolbutamide.
The aim of this study was to investigate the CYPs-mediated metabolism-based interactions of miltirone on CYP1A2, CYP2C9, CYP2D6 and CYP3A4, with their model probe substrates phenacetin, tolbutamide, dextromethorphan and testosterone in pooled human liver microsomes (HLMs), respectively.
The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.
Insulin secretagogues include sulfonylureas (glyburide, glipizide, tolazamide, tolbutamide, glimepiride, gliclazide), which promote insulin secretion; and meglitinides (repaglinide, nateglinide), which promote short-term glucose-stimulated insulin secretion; nateglinide is more specifically an amino acid derivative.