tolazamide


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Synonyms for tolazamide

a drug (trade name Tolinase) used in treating stable adult-onset diabetes mellitus

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5,1 and 2 mg, tablet, oral, 100; amiloride hydrocholoride, hydrochlorothiazide EQ 5 mg anhydrous 50 mg, tablet, oral 100; amitriptyline hydrochloride 150 mg, tablet, oral 100; ampicillin/ampicillin trihydrate 250 and 500 mg, capsule, oral, 100; benzonatate 100 mg, capsule, oral, 100; bumetanide 1 and 2 mg, tablet, oral, 100; cholestyramine EQ 4 gm resin/packet, powder, oral, 60; cyclobenzaprine hydrochloride 10 mg, tablet, oral, 100; minocycline hydrochloride EQ 50 and 100 mg base, capsule, oral; temazepam 15 and 30 mg, capsule, oral, 100; tolazamide 250 mg, tablet, oral, 100; and verapamil hydrochloride 240 mg, tablet, extended-release, oral, 100.
Generic name Brand name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase, PresTab, Micronase tolazamide Tolinase tolbutamide Orinase
Their generic names include tolbutamide, chlorpropamide, tolazamide, acetohexamide, glipizide and glyburide.
The first-generation sulfonylureas currently available are chlorpropamide (Di-abinese), tolazamide (Tolinase), and tolbutamide (Orinase).
First-generation sulfonylureas, including chlorpropamide (Diabinese[R]), tolbutamide (Orinase[R]), tolazamide (Tolinase[R]), and acetohexamide (Dymelor[R]), have substituents that are small, polar, and hydrophilic, making them more water-soluble and less potent, in the second and third-generation sulfonylureas, (glyburide [Micronase[R]], glipizide [Glucotrol[R]], gliclazide [Diamicron[R], Dianorm-In[R]], and glimepiride [Amaryl[R], DIAPRIDE[R]]), substituents are large, nonpolar, lipophilic groups that more readily penetrate cell membranes and therefore are more potent in increasing insulin release (Spiller & Sawyer, 2006).
These medications--such as tolbutamide, tolazamide, glipizide, and glyburide--were not independently studied, but were instead used in comparison groups for several studies of other hypoglycemic drugs.
Other Names for This Medicine Generic Name Brand Name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase PresTab, Micronase tolazamide Tolinase tolbutamide Orinase
Acetohexamide and tolazamide are not recommended even though they have mild diuretic activity, because their metabolic and excretion patterns may result in accumulation and hypoglycemia.
The first generation sulfonylureas include tolbutamide (Orinase[R]), chlorpropamide (Diabinese[R]), and tolazamide (Tolinase[R]).