Result: Structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles
with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis.
Variably extensive and variably severe inflammatory and fibrotic changes caused by tobacco smoke that are found in the terminal bronchioles
and respiratory bronchioles are termed, respectively, membranous bronchiolitis and respiratory bronchiolitis.
The amount of pigment in terminal bronchioles
was significantly correlated with the amount of pigment in respiratory bronchioles, particularly for mineral dusts (linear regression analysis, [R.
Abbreviations: a, alveolus; ad, alveolar ducts; bv, blood vessel; e, airway epithelium; tb, terminal bronchioles
7% in the terminal bronchiolar cross-sectional area per lung, compared with that of the control lungs, and a reduction of 89% in the total number of terminal bronchioles
The most frequent lung lesion cases are cellular-looping enhancement of the lung pattern due to sclerosis (infiltration, fibrosis) of interstitial tissue, apparition of small focused changes in the interstitial tissue and in the terminal bronchioles
, in small blood vessels, the shadowing focuses in the lung fields and "frosted glass" zones.
First, a clear topographic extension of the lesions was perceptible between the first and the last day of infection, with centrifugal spreading from the terminal bronchioles
or the alveoli adjacent to the airways.
They also found the virus attaches mostly to alveolar macrophages, including some other cells in the terminal bronchioles
However, lung biopsy did not demonstrate organizing pneumonia in the terminal bronchioles
or alveolar spaces characteristic of BOOP.
As terminal bronchioles
penetrate more deeply into the lungs, they divide into microscopic respiratory bronchioles.
Emphysema includes abnormal enlargement of the airspaces distal to the terminal bronchioles
with destruction of their walls but without obvious fibrosis (American Thoracic Society, 1995).
The first 16 subdivisions of the bronchi ending in terminal bronchioles
are called the conducting airways.
10]), because such particles can reach the terminal bronchioles
and alveoli (6).