At the initiation of tamoxifen
therapy, the average age of the positive group was 9 years older than that of the negative group.
also used in the other treatments like McCune-Albright syndrome, Infertility, Gynecomastia, Angiogenesis, Gene Expression, Riedel's Thyroiditis.
treatment in mice has also been found to enhance clearance of the antibiotic-resistant bacterial pathogen MRSA and reduces mortality.
This was a key finding of SOFT (Suppression of Ovarian Function Trial), a randomized comparison of adjuvant tamoxifen
or exemestane plus ovarian suppression versus tamoxifen
alone in 3,047 patients in 25 countries, making this the largest randomized trial ever conducted in premenopausal women with hormone receptor-positive breast cancer.
Anyone currently on Tamoxifen
treatment (or considering it) owe it to themselves to become aware of the bigger picture
A study reported in the journal Breast Cancer Research and Treatment was the first to discover that your body needs vitamin D to metabolize tamoxifen
and boost its effectiveness.
is widely used to treat estrogen-receptor-positive (ER-positive) breast cancer and is generally prescribed for 5 years of daily use once the cancer has been excised.
for five years, which is the current practice, is known to reduce death rates by around a third during the first 15 years after diagnosis.
Bioactivation of tamoxifen
to endoxifen depends in large part upon the function of the P450 enzyme CYP2D6.
And it confirms tamoxifen
remains an important treatment for breast cancer, particularly in pre-menopausal women not suitable for the newer drugs aromatase inhibitors.
This study gives additional support for the notion of five years of tamoxifen
and its benefit," says Saeed Sadeghi, MD, a breast oncologist at UCLA's Jonsson Comprehensive Cancer Center.
This finding may be of great potential benefit in chemotherapy of breast cancer; since much lower doses of tamoxifen
may be needed to produce the same cytotoxic effect and side effects will be reduced.
SAN ANTONIO -- Breast cancer patients who took the antidepressant paroxetine during their course of tamoxifen
therapy were up to 91% more likely to die from their disease than were those who did not take the two drugs together, according to a retrospective, population-based cohort study conducted in the Canadian province of Ontario.
ISTANBUL, TURKEY -- Tamoxifen
, long a workhorse for the treatment and prevention of breast cancer, continues to show promise as a novel antimanic agent.
5 years of tamoxifen
experienced a 19% reduction in risk of breast cancer recurrence (BCFS) (HR=0.