The subthalamic nucleus
projects excitatory neurons to the internal globus pallidus, which then sends inhibitory signals to the thalamus and, ultimately, the cortex (Helie et al.
This finding paved the way for the application of high frequency deep-brain stimulation (DBS) of the subthalamic nucleus
, a technique now used worldwide for advanced Parkinson's disease patients.
17) In FTLD-tau (PSP), there is notable neuronal loss and gliosis in the subthalamic nucleus
, lateral thalamic nucleus, globus pallidus, and cerebellar dentate nucleus, where grumose degeneration of presynaptic terminals around dentate neurons is often prominent and can be demonstrated with immunostains for synaptophysin.
Among patients stimulated in the subthalamic nucleus
, the score improved from 42.
Effect of the subthalamic nucleus
on the ECoG activity during exercise
These results indicate that verbal fluency deficits, the most frequent cognitive side-effect after DBS of the subthalamic nucleus
, are probably secondary to surgical implantation," they wrote.
Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus
in the primate in MPTP model of parkinsonism.
Patients with Parkinson's have reduced levels of a chemical - GABA - in part of the brain known as the subthalamic nucleus
The OCD data also suggest reasonable efficacy and safety for the VC/VS, inferior thalamic peduncle, and subthalamic nucleus
targets, but not the nucleus accumbens.
The most commonly targeted areas are the ventral intermediate thalamic nucleus (Vim), the globus pallidus internus (GPi), and the subthalamic nucleus
A study published online March 19 in Science shows that the technique exerts its effect on axons that feed into the subthalamic nucleus
, rather than on the neurons in that structure.
1-3) Derived from the older drug amantadine, memantine dampens output from the subthalamic nucleus
, potentiates dopamine release and attenuates degeneration of dopaminergic neurons.
A cross-sectional study of DBS of the subthalamic nucleus
and the internal segment of the globus pallidus on force control and coordination revealed that stimulation led to increases in maximum pinch force production and improvements in force control parameters in a bimanual task.
Recommended Usage: A programmable, battery-operated pulse generator, placed subcutaneously under the clavicle, is connected to electrodes implanted in the subthalamic nucleus
or globus pallidus.
Since transient "positive" local signs are often encountered as a manifestation of neurologic events associated with a small acute hemorrhage, as illustrated by hemiballismus associated with hemorrhage in the subthalamic nucleus
, this case provides substantial support for the concept that central tinnitus might indeed represent a pathologic activation of neural networks of nonspecific auditory perception.