According to the widely accepted hypothesis, hyperkinetic movement disorders occur due to the loss of subthalamic nucleus
control on the internal segment of the globus pallidus (GPi), which leads to disinhibition of the thalamus.
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There are studies in literature which report that this syndrome may be the first to arise following DBS for the subthalamic nucleus
and globus pallidus (5,6).
Statistical analysis of 168 bilateral subthalamic nucleus
implantations by means of the probabilistic functional atlas.
A quick and universal method for stereotactic visualization of the subthalamic nucleus
before and after implantation of deep brain stimulation electrodes.
The subthalamic nucleus
is often atrophied and the substantia nigra is depigmented.
This condition is a result of absent subthalamic nucleus
inhibition, which increases motor activity through the motor thalamus.
In animal studies, gamma-aminobutyric acid antagonists can cause a lesion in the subthalamic nucleus
inducing contralateral hemichorea.
Dorsal striatum: A pair of nuclear masses that form the basal ganglia, along with the subthalamic nucleus
and the substantia nigra.
Researchers evaluated 89 patients who were stimulated in a part of the brain called the globus pallidus interna and 70 patients who were stimulated in a different part of the brain called the subthalamic nucleus
The basal ganglia (BG) consists of six extensively interconnected nuclei, the caudate nucleus, putamen, globus pallidus, substantia nigra, amygdala (archistriatum) and subthalamic nucleus
All received the Libra DBS device, a constant-current subthalamic nucleus
Patients with Parkinson's have reduced levels of a chemical - GABA - in part of the brain known as the subthalamic nucleus