Research shows that patients who received SLCO1B1 genotype-guided therapy were more likely to fill their statin
prescription, take the medication as directed, and ultimately lower their LDL cholesterol.
But the new findings suggesting such overwhelming benefit from statin
treatment in these patients indicates that "statin
use should not be avoided" when patients with liver disease would otherwise qualify for statin
Increased rates of cancer, cataracts, diabetes, cognitive impairments, and musculoskeletal disorders more than offset the modest cardiovascular benefits of statin
Lead investigator Anthony Keech, Professor of Medicine, Cardiology and Epidemiology at the University of Sydney said "These results resolve a major uncertainty about the value of treating women with statin
therapy, and reinforce the need for recommendations to treat women to be included in national and international guidelines.
Then in April 2013, Murtola reported that statin
use was associated with a 66% reduction in the risk of dying from breast cancer.
of of " He suggests it may be that people taking a tablet that they think is a statin
complain of myalgia, "but when you look at the people who complain, they're older peopl " He suggests it may be that people taking a tablet that they think is a statin
complain of myalgia, "but when you look at the people who complain, they're older peopl HEALTH HEALTH who get muscle aches, or people who exercise and get more muscle aches", he notes.
One limitation of the Texas study is that the relationship between statin
dosage and cataract risk was not considered.
It was found that the adjusted hazard ratios (HRs) for dementia were significantly inversely associated with increased daily or total equivalent statin
were generally associated with a reduced risk of Parkinson's, but the same was not true for water-soluble versions of the drugs.
The effect seems to be strongest in the first 120 days after initiation of statin
Nonetheless, clinicians should prescribe the lowest effective statin
dose to avoid this and other possible complications.
They found that every use of any statin
was associated with a significant increase in prostate cancer risk (OR = 1.
Of the two million study participants, about 225,000 were new statin
Patients taking statin
drugs were almost 50% less likely to die from flu, researchers reported on Thursday in a study providing more evidence the cholesterol-lowering drugs help the body cope with infection.
Harriet Rosenberg and Danielle Allard from the Women and Health Protection group authored an extensive report, "Evidence for Caution: Women and Statin
Use", which reviews all the major studies, looks at benefits and safety assessments, and explores the controversies surrounding cholesterol guidelines.