High HbF level in RBCs protects them from sickling
, the phenomenon responsible for clinical manifestation of the haemoglobinopathy.
A total of 50 sickle cell disease children aged between 5 to 15 years of either sex were evaluated clinically and were screened by sickling
test and diagnoses confirmed by hemoglobin electrophoresis and were leveled as case (Both AS and SS).
The morbidity in sickler pregnant women is higher with an increase in sickling
crisis in both antenatal and postnatal periods.
Bergeron et al demonstrated that only 45 min of brisk walking at 33degC significantly increased erythrocyte sickling
in SCT carriers6.
Clearly the methodologies need to be questioned, since the sickling
test is sensitive enough to detect AS.
Were those four deaths in basic training due to having the sickle cell trait, or was the sickling
of the cells a manifestation that happened after their deaths?
This alteration, exertional sickling
, can pose a grave risk for some athletes.
of the blood cells is usually not permanent and these sickled cells can regain their normal shape with reoxygenation and rehydration (Kinney et al.
This can lead to these small blood vessels getting blocked which then stops the oxygen from getting through to where it is needed, a process known as sickling
What surprised the researchers, she said, was the observation of sickling
within the decidual vasculature with stasis and infarction-"a phenomenon that had not previously been reported.
Other known precipitants include dehydration, acidosis, and hypoxemia, which promote sickling
To see whether this prevented blood cells from sickling
, they injected the marrow into healthy mice whose own marrow had been irradiated and wiped out.
HIP NECROSIS: Developing a painful limp, found in all the phenotypes is due to blood flowing too slowly in the vessels of the joint, causing sickling
within the vessels, with blockages occurring in the bone surface which sloughs off.
Stressors for Red Blood Cell Sickling
* High altitudes (over 10,000 feet) * Extremes in temperature, especially cold * Infections * constructive clothing * Vasocontricting drugs * Smoking or second-hand smoke * Dehydration * Extreme stress or fatigue
The Comprehensive Sickle Cell Center provides comprehensive care for more than 400 children with sickling
disorders, and has a commitment to psychosocial as well as medical issues.