Two sequential trials
have found that raloxifene protects against breast cancer: the Continuing Outcomes Relevant to Evista (CORE) trial and the Multiple Outcomes of Raloxifene Evaluation (MORE) trial.
This brand new module allows investigators to design, simulate and monitor superiority and non-inferiority group sequential trials
for time-to-event endpoints in which the patient enrollment is non-uniform, the hazard rates of the treatment arms change over time, and patients drop out at different rates on the two treatment arms.
Combination antipsychotic therapy is prevalent and often is used before trying sequential trials
of single antipsychotics, said Dr.
Includes new or expanded material on study management, multi-centre studies, sequential trials
, bias and different methods to remove confounding in observational studies, multiple comparisons, ROC curves and checking assumptions in a logistic regression analysis
Guidant's participation through piloting SPIRIT III will provide the opportunity to evaluate XIENCE V in both Japan and the United States concurrently in the same clinical trial, as opposed to conducting separate sequential trials
in each country.