Cassidy was prescribed a sedating antidepressant, amitriptyline (Elavil or Endep), which has significant analgesic effects that helped manage the peripheral neuropathy resulting from diabetes and antiretrovirals.
When assured that mirtazepine (Remeron), a sedating antidepressant, will help her sleep as well as treat her depression, she agrees to give it a chance.
This increased to 70% if they were on a sedating allergy medication at the time of their exam;
28% of those on hay fever medication in the study were on a sedating anti-histamine, despite the wide availability of effective non-sedating treatments and current treatment guidelines advocating their use over sedating medication.
A 'once a day' combination product such as COL 118 allows patients to take full advantage of the beneficial effects of a short acting sedating
antihistamine at bedtime in addition to the benefits of a longer acting non-sedating
antihistamine during the course of the day" said Michael Heffernan, R.
Collegium's patented combination product incorporates both a sedating
antihistamine in a modified release formulation.
The once a day treatment associated with this product allows patients to take full advantage of the beneficial effects of a sedating
antihistamine at bedtime in addition to the benefits of a non-sedating
antihistamine during the course of the day.
The medication used has a calming, sedating
effect, allowing patients to approach the end of life in a peaceful state.
The ability of aromatic oils to alleviate agitation could reduce the need for sedating
medications used to calm patients with Alzheimer's disease.
The patent relates to compositions comprising both a sedating
and a non-sedating
antihistamine in a single dosage form.
Unlike current practices for withdrawing addicted patients from alcohol, cocaine, or other addictive stimulants, the HANDS protocols are completed within 2-3 consecutive days of treatment, eliminate the use of sedating
medications, require no tapering or washout period, significantly reduce or eliminate withdrawal symptoms and have substantially higher completion rates.