secretase


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a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)

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References in periodicals archive ?
Gamma secretase is an enzyme that cleaves a set of transmembrane proteins, including BCMA.
Kitamoto, "Novel [alpha]- secretase cleavage of Alzheimer's amyloid [beta] precursor protein in the endoplasmic reticulum of COS7 cells," Neuroscience Letters, vol.
For instance, inhibition of [beta]- and [gamma]-secretases will interfere with proteolytic processing of other secretase substrates such as sialyltransferase (35) and Notch, (33,36) respectively, possibly resulting in perturbation of the immune system.
The company intends to file an IND on the lead modulator of gamma- secretase in 2012.
The company announced semagacestat, a gamma secretase inhibitor, endured two on-going long-term studies, during which the drug not only failed at slowing Alzheimer's progression, but also affected the ability to perform activities of daily living.
Gamma secretase (GS) is a membrane-embedded multi-protein enzyme composed of presenilin/nicastrin/Aph 1 and Pen 2 [1].
The pill semagacestat inhibits an enzyme called gamma secretase thatAAEs tied to amyloid production.
Working with laboratory mice, the researchers tested whether the drug DAPT--one of a class of drugs called gamma secretase inhibitors that is being studied as a treatment for AD--could reduce damage associated with TBI.
There is compelling evidence that sAPPbeta, the ectodomain of amyloid precursor protein (APP) shed through beta secretase cleavage, is an important component in the pathogenesis of AD," said Joe Bertelsen, neuroscience product manager, Covance.
The findings, published in the journal Nature, show drugs called gamma secretase modulators work to stop the build-up of a protein thought to trigger Alzheimer's.
The problem with most proposed methods of blocking beta secretase, the study found, is that they are designed to work outside of the affected brain cells.
Other research has shown that statins (cholesterol-lowering drugs) and estrogen activate a form of secretase that destroys A[beta], says Gandy.
Miele's study shows that inhibiting gamma secretase can block intercellular communications in cancer cells as well.
Phase 2 Study to Assess Safety, Tolerability, Pharmacokinetics of Gamma Secretase Modulator Program
Eisai Co Ltd, a Japan-based pharmaceutical company, announced yesterday that enrollment has commenced in Japan for MISSION AD1, a global Phase III clinical study of the in-house developed oral beta secretase cleaving enzyme (BACE) inhibitor elenbecestat in patients with early Alzheimer's disease (AD).