provirus


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  • noun

Words related to provirus

cDNA copy of the RNA genome of a retrovirus

References in periodicals archive ?
Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease.
An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells.
This step is catalysed by the viral enzyme IN, and from this point on the provirus will forever form part of the cellular genome.
We know that provirus does not make virus until the cell containing it is 'activated'.
Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction.
After the provirus is integrated into the host genome, the transcription of HIV genes and the formation of new viral particles may begin.
In Vanconver, John Mellors from the Multicenter AIDS Cohort Study (MACS) presented the famous study demonstrating that viral load in chronic infection predicts rate of progression to AIDS (Mellors 1996), and David Ho and Marty Markowitz presented their famous eradication hypothesis, suggesting that if HIV levels in the peripheral blood could be suppressed by combination antiretroviral therapy (ART) for several years, residual amounts of integrated HIV provirus in human cells might eventually be eliminated from the body (Ho 1996, 1998).
Host factors that affect provirus stability and silencing
Although this patient is still HIV positive (in terms of antibodies) and has probably minor traces of provirus somewhere, and HIV eradication was not achieved, The Infectious Diseases team of General Hospital can declare that he his functionally cured from HIV for 14 years now.
Similarly, these authors observed a tendency for increased provirus load in cattle with G/G homozygote compared to A/A homozygote or A/G heterozygote.
Rous sarcoma virus infection of synchronized cells establishes provirus integration during S-phase DNA synthesis prior to cellular division.
Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers.
While HIV-1 latency is likely to be a multifactorial process, we have shown that inhibiting the methylation of the provirus contributes to an almost complete reactivation of latent HIV-1," said lead author Steven E.
Sites of simian foamy virus persistence in naturally infected African green monkeys: latent provirus is ubiquitous, whereas viral replication is restricted to the oral mucosa.
Human immunodeficiency virus type I provirus is demonstrated in peripheral blood monocytes in vivo: a study utilizing an in situ polymerase chain reaction.