proto-oncogene


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Related to proto-oncogene: tumor suppressor gene
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  • noun

Words related to proto-oncogene

a normal gene that has the potential to become an oncogene

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References in periodicals archive ?
Mutation of the kit proto-oncogene results in a CD 117 receptor that is constantly stimulated without the presence of the stem-cell growth factor.
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
Previous research had established that Ras, a proto-oncogene, is abnormally expressed in up to 25 percent of human lung cancers; but, researchers did not understand the specific cellular events by which abnormal Ras expression leads to transformation.
It is noted that a locus, representing the proto-oncogene BCL3, resides on at 19q13 (OMIM: http://www.
The BRAF gene encodes B-Raf proto-oncogene serine/threonine-protein kinase (B-raf), a protein involved in cell signaling and cellular growth and differentiation.
The VHL gene is a tumor suppressor that regulates extracellular matrix formation, the cell cycle, and transcription of vascular endothelial growth factor, a proto-oncogene that promotes angiogenesis.
4,5) In approximately 40% of sporadic medullary thyroid cancer, and in up to 100% of hereditary medullary thyroid cancer cases, the cancer is caused by specific mutations in the RET proto-oncogene, a receptor tyrosine kinase, that transduces signals for cell growth and differentiation.
Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations.
A variety of carcinogens have been shown to induce ras mutations in animal and human tumor models, and ras proto-oncogene mutations have been implicated in the development of many malignancies including pancreatic and breast cancers.
In contrast, testing an individual with multiple endocrine neoplasia type-2 (MEN-2) for the RET proto-oncogene can avoid medullary carcinoma if the individual is positive and undergoes a prophylactic thyroidectomy.
The proto-oncogene K-Ras is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies," said Yi Liu, Ph.