NASDAQ: XBIO) has commenced patient enrollment in its Phase 2 clinical study of XBIO-101 (sodium cridanimod) in conjunction with progestin
therapy for the treatment of endometrial cancer in patients who have either failed progestin
monotherapy or who have been identified as having progesterone receptor negative (PrR-) tumors, the company said.
In a large 3-year prospective study of more than 2,900 women using the progestin
implant or the copper IUD (Para-Gard), use of the progestin
implant was associated with a higher rate of reported acne than the copper IUD (18% vs 13%, respectively; relative risk, 1.
Virexxa may improve sensitivity to progestin
therapy in subjects with advanced or recurrent PrR-negative tumors.
-only injectable contraception: Depot medroxyprogesterone acetate (DMPA or Depo-Provera, Pfizer) is a long-acting progestin
given as a single intramuscular injection every 13 weeks.
Although estrogen with or without progestin
lowered the risk for osteoporotic fracture, it offered no other clear benefit in terms of reducing risk for chronic disease.
is also the active ingredient in the long-acting injected contraceptive Depo Provera (medroxyprogesterone) and the intrauterine device (IUD) Mirena.
In the Women's Health Initiative (WHI) randomized trial, estrogen plus progestin
was associated with an increase in both breast cancer incidence and mortality.
The results of the present study suggest that genistein aglycone is an effective alternative to a progestin
in this group of women.
from Finland (Obstet Gynecol 2009; 114: 1197-1204) compared continuous with sequential progestin
additions to oestrogen therapy in women over the age of 50 years.
Although all regimens were associated with at least some decreased risk, the strongest was a 48% risk reduction among past users of estrogen plus progestin
, Jill R.
The results found health risks associated with estrogen plus progestin
persist even a few years after stopping the drugs.
Furthermore, the lower the dose of one particular progestin
, the lower the risk of ovarian cancer.
Estrogen Plus Progestin
Study Stopped Due to Increased Breast Cancer Risk, Lack of Overall Benefit.
After years of debate about the safety of hormone replacement therapy in menopause, a major medical group last week revised its position, stating that estrogen and progestin
drugs may actually protect the hearts and bones of certain women.
Hormone replacement therapy (HRT) can mean either taking estrogen alone or taking estrogen plus progesterone or progestin
, a synthetic hormone with effects similar to those of progesterone.