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  • noun

Synonyms for proenzyme

any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active


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References in periodicals archive ?
Whilst my retrospective review of patients treated at Dr Kenyon's practice indicated that a proenzyme treatment has the potential to meaningfully extend life, free from serious side effects normally associated with standard therapies, we are determined to fully assess the behavior of the drug in animals prior to conducting human trials.
Several mechanisms regulate MMP-9 activity, including gene transcription, proenzyme activation, and endogenous inhibitors such as tissue inhibitors of metalloproteinases (TIMPs).
Additionally, the subunit apo A is highly homologous to the fibrinolytic proenzyme plasminogen, and lipoprotein(a) can inhibit plasminogen activation along with its ability to stimulate secretion of plasminogen activator inhibitor-1 (PAI-1).
One form, termed BPSA, is associated with benign prostatic hyperplasia, while proenzyme or precursor forms, termed pPSA, are associated with prostate cancer.
Caspase-3 is synthesized as inactive proenzyme, where upon cleavage at Asp175/Ser176, is converted to the active enzyme.
Activation of the proenzyme involves proteolytic removal of the N-terminal proregion containing the cysteine switch motif conserved in matrix metalloproteinases (18).
Proenzyme prostate specific antigen (pPSA) does a better job of detecting prostate cancer and helping prevent unnecessary biopsies than free PSA (fPSA) does, according to the results of a preliminary study reported in the February issue of Urology.
It is a cytosolic protein as an inactive 32-kDa proenzyme and is activated by proteolytic cleavage into the 20 kDa (p20) and 11 kDa (p11) active subunits.
The protease to be measured converts a proenzyme into an active enzyme (detection enzyme), and the activity of the latter is detected (Fig.
Urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are serine proteases that catalyse the conversion of a proenzyme, plasminogen, to active plasmin and play important roles in thrombolysis (Blasi et al.
Binding to uPAR enhances the activation of uPA proenzyme because of the proximity of cell-surface-bound plasminogen.
Proapoptotic stimuli first lead to the activation of so-called initiator caspases such as caspase-8, which in turn cleave inactive proenzyme forms of so-called effector caspases such as caspase-3 and caspase-7.
1] uPA is secreted as an inactive proenzyme, which localizes on the cell surface by binding to a specific glycolipid-anchored receptor, uPAR (2).