prion


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Related to prion: Prion disease, Prion protein
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  • noun

Words related to prion

(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid

References in periodicals archive ?
The finding illustrates the hardiness of prion infectivity and the potential risks associated with prion transmission, potentially through surgery, blood transfusion or tissue donation.
The research also demonstrates the potential of human stem-cell derived astrocytes to notably reduce, and in many instances, replace animal studies of human prion disease.
The field has grown so much since the 2004 second edition of Prion Biology and Diseases that Prusiner decided to split this edition into two volumes, this one devoted primarily to prion biology, with an emphasis on functional or physiological prions, but also with an overview of prion diseases.
Although the sequence homology of PrP among mammals is high, the ability of particular prion strains to cause disease in different species is determined by the conformational compatibility between a given strain and the host [PrP.
Prions are proteins that change shape and shift tasks, and then trigger other proteins to make the same change.
A related prion illness is Chronic Wasting Disease (CWD) and it has been identified in deer, elk and moose in North America.
An easy-to-use diagnostic test would let doctors clearly differentiate prion diseases from other brain maladies.
The genetic focus of prion disease lies in the Prnp gene, which is located on chromosome 20 in humans and is a member of the Prn gene family.
Germ cell mutations in straussler- prion protein gene.
The new study, led by The Scripps Research Institute (TSRI) Professor Corinne Lasmezas and performed in collaboration with TSRI Professor Emeritus Charles Weissmann and Director of Lead Identification Peter Hodder, used an innovative high-throughput screening technique to uncover compounds that decrease the amount of the normal form of the prion protein (PrP, which becomes distorted by the disease) at the cell surface.
Prions cause disease by interacting with normally folded proteins and causing them to misfold.
Our data on prion structure is an important step toward understanding prion infection," Stubbs said.
of Melbourne, Australia) assembles a collection of protocols from 13 different laboratories in five countries covering basic science and diagnostic areas of prion research.
El concepto de prion fue inicialmente acunado para designar al agente etiologico infeccioso de las encefalopatias espongiformes de los mamiferos, una clase de enfermedades neurodegenerativas.
Prion diseases can be inherited, as in fatal familial insomnia (the Italian family that couldn't sleep): they include other fatal neurological disorders such as Mad Cow and scrapies.