At 20 years, with the only treatment difference between the two original study arms being that the pravastatin
group had been on statin therapy for an additional 5 years, the 20-year coronary heart disease mortality rate in the original statin group was reduced by 27%, compared with the original controls.
Moreover, pitavastatin 4 mg continued to demonstrate significantly greater LDL-C reduction compared with pravastatin
40 mg after 52 weeks of treatment in the HIV-infected adult population with high cholesterol.
The findings show that while no adverse cognitive effects were observed in rat performance for simple learning and memory tasks for atorvostatin, pravastatin
impaired their performance.
was the reference drug in all analyses.
LIVALO 4 mg showed superior LDL-C reduction compared with pravastatin
40 mg after 12 weeks of therapy.
87 mmol/L)], and the West of Scotland Coronary Prevention Study (4) used pravastatin
in men without clinical coronary disease [average TC, 272 mg/dL (7.
Group 1 (n=30) received pravastatin
at a dose of 10 mg/day, Group 2 (n=29) was given 40 mg/day, and Group 3 (n=34) served as the control group and received no lipid-lowering drugs.
In pivotal Phase III studies comparing pitavastatin with atorvastatin,(2) simvastatin(3) and pravastatin
,(4) the overall safety profile of pitavastatin was demonstrated, with low incidences of adverse events (AEs).
In that study, 38 coinfected patients were safely treated with atorvastatin, pravastatin
, and rosuvastatin over a 6-month time period (20).
Samani, a cardiologist at the University of Leicester in England, and his colleagues assessed telomere length in the white blood cells of Scottish men entering a trial of the cholesterol-lowering statin drug pravastatin
Simvastatin and pravastatin
were on the PDL, but atorvastatin was not.
On January 31 the FDA announced that the Sustiva (efavirenz) package insert had been changed "to include drug-drug interaction information regarding coadministration of efavirenz with rifampin, diltiazem, itraconazole, voriconazole, atorvastatin, pravastatin
, simvastatin, pimozide and bepridil.
The data came from the intensive-treatment arm of the Pravastatin
or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial (N.
Tokyo, Japan, Feb 20, 2006 - (JCN) - Sankyo, a group company of Daiichi Sankyo, has announced its plan for pravastatin
, a hyperlipidemia drug, in the US.
A second study found the cholesterol-lowering drug pravastatin
is highly effective in lowering the risk of heart attack and other cardiovascular events in patients with diabetes or chronic kidney disease (CKD).