point mutation


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Related to point mutation: Insertion mutation, Deletion mutation
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  • noun

Synonyms for point mutation

(genetics) a mutation due to an intramolecular reorganization of a gene

References in periodicals archive ?
One specimen in this study contained a novel, single, point mutation in ompA.
In the adverse reaction group, nine children with the specific UGT point mutation developed leukopinia.
All four patients presented wild-type sequences (no point mutation either at codon 55 or at 57) at the P.
University of British Columbia (Vancouver, CA) has patented a single point mutation in the human lipoprotein lipase gene which results in an A.
The change of a single molecule, called a point mutation, in the genes that Hughes examined can alter the shape of a surface protein, disguising it from the immune system.
What we found is that if you have a single point mutation in the genome that can give rise to resistance to both drugs at the same time, the game is over.
A point mutation is an insertion, deletion, or substitution of a single nucleotide or base.
The paper "Targeted therapy and the T315I mutation in Philadelphia-positive leukemias" by researchers Simona Soverini and colleagues at the University of Bologna, Italy (Haematologica Volume 92, pages 401-404) offers insight into the growing therapeutic challenge presented by the T315I Bcr-Abl point mutation in patients with chronic myeloid leukemia (CML).
A point mutation at R345T which appears to result in loss-of-function when re-expressed in the mouse was found in 5925 healthy individuals with a heterozygous frequency of approximately 0.
When the mutated gene was translated into a protein, the point mutation led to the substitution of methionine for lysine as the 27th amino acid in this variant of histone H3 protein.
One such reassortment event (shift), rather than a point mutation (drift), appears to explain the emergence of the A/Fujian/411/2002-like strain that caused an epidemic during the 2003 2004 influenza season.
For each point mutation locus, two PCR reactions in separate tubes were carried out in parallel for each DNA sample to amplify the target DNA with each of its two DNA references.
ChemGenex is currently conducting a Phase 2/3 registration-directed study evaluating the use of Ceflatonin([R]) in CML patients who have the T315I Bcr-Abl point mutation that is associated with resistance to imatinib and other tyrosine kinase inhibitors.
In one, point mutation, genes adapt through spontaneous mutations during DNA replication.