The main resistance mechanism of bacteria to penicillin is based on its own production of enzymes, the penicillinases
, which degrade the penicillin before it can have effect (Daum, 2007).
saprophyticus was the exception as the majority of other staphylococci are penicillinase
enzyme has been used in the production of the sensor.
is a specific type of [beta]-lactamase, showing specificity for penicillins, again by hydrolysing the beta-lactam ring.
Also, Penicillin resistant strains will remain resistant to all penicillins except penicillinase
stable penicillins (including Cephalosporins, Carbapenem and Beta lactam/ Beta lactamase inhibitors).
2001), inhibition of penicillinase
activity (Zhao et al.
These antibiotics are not readily affected by cephalosporinase or penicillinase
enzymes produced by certain bacteria .
Penicillin may be rendered ineffective due to the presence of bacteria which produce penicillinase
(Sheldon et al.
The injection is used to treat infections caused by penicillinase
producing staphylococci, which have shown susceptibility to the drug.
However, a combination of a new cephalosporinase and penicillinase
provides inactivation of a broad spectrum of 13-lactam antibiotics, including cephalosporins of the third and fourth generation.
Simple method for detection of penicillinase
producing Neisseria gonorrhoeae.
Reductions were found for all classes of antibiotics other than penicillinase
resistant penicillins but were largest and significant individually for phenoxymethylpenicillins (penicillin V) (7.
Our findings were in agreement with other workers (24,26) who reported that Staphylococci (both penicillinase
negative and positive) were highly susceptible to meropenem.
The increase in the prevalence of both PPNG and TRNG isolates might be due to acquisition of penicillinase
plasmid in the TRNG isolates as transfer of penicillinase
plasmid requires the presence of conjugative plasmid (23).
Immunodiagnosis of childhood pulmonary and extrapulmonary tuberculosis using Mycobacterium tuberculosis ES antigen by penicillinase