Two multicenter, randomized, single-blind studies conducted in 1994 and 1995 reported that 35% of children aged 2 to 12 years treated with oral penicillin V and 37% treated with intramuscular benzathine penicillin G had a positive throat culture result for a concordant serotype of GABHS when tested either 10 to 14 days or 1 month after starting treatment (FIGURE 2).
3) If patient compliance with an initial oral penicillin regimen was poor, then consideration may be given to the use of intramuscular benzathine penicillin G.
A nationwide survey of 481 infectious disease specialists showed that 76% had experienced shortages of intravenous penicillin G since Sept.
The situation concerning penicillin G is "alarming," according to the Infectious Diseases Society of America, which conducted the survey.
congenital syphilis and neurosyphilis, and intrapartum prophylaxis for perinatal group B streptococcal disease), intravenous penicillin G
is the drug of choice.
Bicillin([R]) C-R Pediatric 900/300 is comprised of 900,000 units of penicillin G benzathine and 300,000 units of penicillin G procaine.
Bicillin([R]) L-A is the only formulation of intramuscular penicillin G benzathine that is approved by the U.
Physicians treating neurosyphilis, congenital syphilis, invasive group A streptococcal disease, or leprosy may purchase intravenous penicillin G on an "urgent need" basis, said Elizabeth Wheeler, director of communications for Geneva Pharmaceuticals.
Intravenous penicillin G is a first-line drug for syphilis, invasive group A streptococcal disease, pneumococcal meningitis, penicillin-susceptible community-acquired pneumonia, endocarditis, and meningococcosis.
meningitidis with reduced susceptibility to penicillin G
(MICs from 0.
The recent Sexually Transmitted Diseases Treatment Guidelines issued in 2006 by the Centers for Disease Control and Prevention (CDC) recommends penicillin G
as the preferred treatment of all stages of syphilis.
The treatment failure rate was 35% among 285 children who received a standard 10-day course of oral penicillin V and 37% of 271 who were given standard intramuscular benzathine penicillin G
For example, penicillin G
in appropriate doses is often effective therapy for drug-resistant Streptococcus pneumoniae pneumonia.
Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G
Streptococcal pharyngitis in children: a comparison of four treatment schedules with intramuscular penicillin G