Catheter closure of moderate- to large-sized patent ductus arteriosus
using the new Amplatzer duct occluder: immediate and short-term results.
Causes of patent ductus arteriosus
include persistent pulmonary hypertension of the newborn, respiratory distress syndrome, and Down syndrome.
patent ductus arteriosus
and ventricular septal defects), hemimegalencephaly, facial hemihypertrophy, renal malformations (e.
Another defect, patent ductus arteriosus
, allows blood to mix between the pulmonary artery and the aorta.
Alead article in the New England Journal of Medicine describes a retrospective cohort study comparing clinical outcomes in patients with patent ductus arteriosus
(a common cardiopulmonary complication of prematurity) who had undergone standard surgical closure of the ductus with patients who had undergone transcatheter placement of a new device designed to occlude the ductus nonsurgically.
Of the 43 types of birth defects studied, only three showed a significant correlation between incidence and maternal age, and two of those -- a heart defect called patent ductus arteriosus
and a stomach defect called hypertrophic phyloric stenosis -- actually decreased with increasing maternal age, the researchers report in the March 2 LANCET.
Global Markets Direct's, 'Patent Ductus Arteriosus
- Pipeline Review, H1 2012', provides an overview of the Patent Ductus Arteriosus
The structural heart defect closure devices segment is sub-divided into artial septal defect closure devices, ventricular septal defect closure devices, patent foramen ovale, patent ductus arteriosus
, and left artial appendage closure devices.
In most patients, these alterations cause a severe short circuit from left to right--similar to that of patients with left-to-right shunts, such as patent ductus arteriosus
or VSD--leading to the development of congestive heart failure with dyspnea and hepatomegaly (5) mainly during the first year of life or later in childhood.
Successful ligation of the persistently patent ductus arteriosus
was achieved on the first attempt by Gross and with equal success with his second patient.
Therapeutic management of patent ductus arteriosus
Additional echocardiographic findings were coarctation of aorta (CoA) with patent ductus arteriosus
(PDA) in case 1, abnormally partially venous return anomaly in case 2 and mitral valve prolapse (MVP) in case 4.
Both had the heart problem patent ductus arteriosus
- an important blood vessel hadn't closed.
3) The syndrome's variable components include: lung hypoplasia (right more commonly affected than left), partial anomalous pulmonary venous drainage (to right atrium, coronary sinus, inferior vena cava (IVC), or hepatic circulation), absent or small pulmonary artery, systemic arterial supply to the lung, cardiac anomalies (atrial septal defect (ASD), ventricular septal defect (VSD), patent ductus arteriosus
(PDA), tetralogy of Fallot, coarctation, hypoplastic left heart or endocardial cushion defects), diaphragmatic hernia, and anomalies of the bony thorax or thoracic soft tissues.
Twelve of the 13 infants had at least one morbidity, including retinopathy of prematurity, intraventricular hemorrhage, patent ductus arteriosus
, or sepsis, and many of them had multiple comorbidities.