The first serious political exploration of nullification as a constitutional right was cultivated in the New England nullification and secession movement that seized the region from 1804 to 1814.
The level of discussion was very high and gave to the Jeffersonian doctrine of state interposition and nullification a political prominence that it did not have before.
Next in philosophical importance to the Hartford Convention was South Carolina's nullification of the tariff in 1832.
The ubiquitous practice of nullification in antebellum America is testimony to a dynamic federal system, operating on a continental scale in which the agents are not individuals, but corporate entities called States, each seeking to preserve its own valuable way of life in a constitutional modus vivendi with the other States.
Fifth, a form of state nullification appears in that two thirds of each house of a state legislature can impeach any federal agent in the state, which agent would then be tried in the Confederate Senate.