Although most cells are capable of de novo nucleoside
biosynthesis, the cellular nucleotide pool is preferentially maintained via the more energy efficient "salvage pathway" involving recycling and uptake of extracellular hydrophilic nucleosides
by specialized integral membrane proteins, termed nucleoside
transporters (NTs) (Molina-Arcas et al.
A novel nucleoside
reverse transcriptase inhibitor candidate - EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) - has shown antiviral activity toward highly resistant HIV strains.
We discovered the structure of the transporter molecule, and now we believe it is possible to improve nucleoside
drugs to be better recognized by a particular form of the transporter molecule that resides in certain types of tissue.
Neither Videx nor any other nucleoside
had any impact on cardiovascular disease risk or on these heart disease markers.
TORONTO -- A large, randomized comparison of three standard regimens for the initial treatment of HIV has demonstrated that all three are safe and effective, but a regimen of efavirenz plus two nucleosides
was significantly better at reducing HIV viral load, investigators reported at the 16th International AIDS Conference.
TORONTO -- A large, randomized comparison of three standard regimens for initial treatment of HIV has shown that all are safe and effective, but a regimen of efavirenz plus two nucleosides
was significantly better at reducing HIV viral load, investigators said at the 16th International AIDS Conference.
Reverset is a nucleoside
analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc.
Also, TDM cannot be used for nucleosides
because of their intracellular activity (blood plasma levels may not accurately be a reflection of drug penetration and therapeutic activity).
Approved June 24, 1996 for use in combination with nucleoside
analogues for the treatment of HIV-infected adults experiencing clinical and/or immunologic deterioration.
Analogue Reverse Transcriptase Inhibitors Generic Name Initials Trade Name Manufacturer Didanosine (1990) ddl Videx Bristol-Myers Squibb Lamivudine (1995) 3TC Epivir Glaxo Wellcome Stavudine (1994) d4T Zerit Bristol-Myers Squibb Zalcitabine (1992) ddC HIVID Hoffmann-LaRoche Zidovudine (1987) AZT/ZDV Retrovir Glaxo Wellcome Table 2.
They bind to a cleft on the enzyme that normally locks onto a nucleoside
, one of the building blocks of DNA.
Nasdaq: ISIS) with nucleoside
phosphoramidites at quantities up to 100 kg.
triphosphates and their analogs; chemistry, biotechnology, and biological applications.
Clevudine is an oral, once-daily nucleoside
analog drug candidate for the treatment of HBV that was shown to be well tolerated and potent in previously completed clinical studies.
Although the effect has been associated with both nucleoside
analogue reverse transcriptase inhibitors (NRTI) and protease inhibitors, not all of the drugs in both classes are equal in this regard, prompting investigators to consider new combinations that might have more favorable effects on fat distribution.