nitrogen mustard


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  • noun

Words related to nitrogen mustard

a toxic compound resembling mustard gas in structure

References in periodicals archive ?
Earlier drugs such as nitrogen mustard have poor selectivity between cancer and healthy cells and cause side effects such as nausea and hair loss.
Anthralin was first taken from tree bark and found to effectively treat psoriasis, while topical nitrogen mustard has been used since 1959 for cutaneous T-cell lymphomas.
Treatment of mycosis fungoides and Sezary syndrome Therapy Reference number Skin-directed therapy (early stage disease: stages IA-IIA) Topical steroids 20 Nitrogen mustard 21 Topical carmustine 22 Bexarotene gel 23 Phototherapy * PUVA 24 * Broadband ultraviolet B * Narrowband ultraviolet B (wavelength 311 nm) 25 Radiation (spot or total-body electron beam) 26 Systemic therapy (refractory early stage disease or stage IIB and above) Biologic response modifiers * Retinoids/rexinoids 27 * Interferon [+ or -] PUVA 28,29 * Photopheresis 30 Combined modality treatment 31 Chemotherapy (single agent and multiagent) 32-34 Fusion toxin (denileukin diftitox) 35 Bone marrow transplantation 36,37 Experimental: cytokine therapy PUVA indicates psoralen + ultraviolet A.
The patient received one round of chemotherapy, MOPP-ABV (nine cycles of nitrogen mustard, vincristine, procarbazine, and prednisone [MOPP], alternating with Adriamycin [doxorubicin], bleomycin, and vinblastine [ABV]).
Examples are sulphur mustard, nitrogen mustard, lewisite, and phosgene oxime;
Freezing points of chemical agents Agent Symbol Contact Hazard Vapor Hazard Nerve Tabun GA Extreme Low-Moderate Sarin GB Extreme Extreme Soman GD Extreme Probable VX Extreme Negligibe VR-55 Extreme Probable TGD Extreme Probable Blister Distilled mustard HD Extreme Negligibe Mustard-lewisite HL Extreme Low Nitrogen mustard HN-1 Extreme Low Nitrogen mustard HN-2 Extreme Low Lewisite L Extreme Negligible Nitrogen mustard HN-3 Extreme Low Phosgene oxime CX Extreme Low Blood Hydrogen cyanide AC Low Extreme Cyanogen choride CK Low Extreme Arsine SA Low Extreme Choking Phosgene CG Slight Extreme Diphosgene DP Slight Extreme Table 2.
In 1942, researchers at Yale University tested one such agent, nitrogen mustard, in a human for the first time.
Unlike the more common nitrogen mustard alkylating agents, Lomustine (CCNU) crosses the blood-brain barrier quite effectively due to its high lipid solubility and the relative lack of ion-ization at physiological pH and is used in the treatment of both primary and metastatic brain tumors in patients.