nelfinavir


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Related to nelfinavir: saquinavir, ritonavir
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Synonyms for nelfinavir

a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs

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References in periodicals archive ?
3%) 7-year-old boy who was on 3TC, ZDV and NVP since 4 years (initially given nelfinavir for 1 year) and also completed therapy for TB.
In the NIID group a larger array of protease inhibitors were used: nelfinavir, boosted lopinavir, boosted saquinavir (Table 2).
19] Of note, the PI most commonly used was unboosted nelfinavir, an unacceptable choice given current knowledge.
Purchase and distribution of nelfinavir for the SCALOP2 trial: A multi-centre randomised phase II/III study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer.
But in HER2 breast cancer cells, nelfinavir acts on a chaperone protein called heat shock protein 90, also known as HSP90, which helps stabilize other proteins involved in tumor growth.
A group of patients treated with nelfinavir (n = 172) or indinavir (n = 102) was used as a comparison, but time to failure did not differ by race in either of these treatment groups, thus suggesting that regimen adherence was not the likely explanation.
Major Finding: Of 25 medications tested, 16 were found to inhibit the metabolism of 17R Those with the strongest inhibitory effects were the asthma drug montelukast, and the protease inhibitors nelfinavir and ritonavir, which were associated with 90%-100% inhibition of 17P.
0 420 1,910 AZT-3TC-NFV * AZT, zidovudine; 3TC, lamivudine; NVP, nevirapine; NFV, nelfinavir.
In 381 most of our patients were on a nelfinavir regimen or an efavirenz regimen, and we saw no response difference between the two (Table 1).
FDA-Approved Antiretroviral Agents Nucleoside RTIs Nonnucleoside RTIs Protease inhibitors abacavir (ABC) delavirdine (DLV) atazanavir (ATV) didanosine (ddl) efavirenz (EFZ) darunavir (DRV) emtricitabine (FTC) etravirine (ETV) fosamprenavir (Fos-APV) lamivudine (3TC) nevirapine (NVP) indinavir (IDV) stavudine (d4T) lopinavir/r (LPV/r) zidovudine (ZDV) nelfinavir (NFV) ritonavir (RTV) saquinavir (SQV) tipranavir (TPV) Nucleotide RTI Integrase inhibitor Fusion inhibitor tenofovir DF (TDF) raltegravir (RAL) enfuvirtide (T-20) CCR5 antagonist maraviroc (MVC) Notes: Six fixed-dose combinations are approved by the Food and Drug Administration.
In one study, patients taking combination therapy of nelfinavir with azido thymidine (AZT) had a threefold higher risk of QTc prolongation compared with the nelfinavir group alone [12].
Zidovudine (AZT) (GlaxoSmithKline, London, UK), nelfinavir (Roche-Farma, Barcelona, Spain), gallic acid and ellagic acid (Sigma Aldrich, St.
Dose-escalating study of the safety and pharmacokinetics of nelfinavir in HIV-exposed neonates.
No obstante todos menos uno estaban en triple terapia Asi la combinacion mas habitual era: lamivudina, estavudina y nelfinavir.