These include naphazoline
hydrochloride (HCL), naphazoline
HCL combination products, tetrahydrozoline HCL, oxymetazoline HCL, and xylometazonline.
Drug options Pseudoephedrine (Su-dafed 12/24), phenylephrine (Sudafed PE, 4-Way Fast-Acting nasal spray), naphazoline
(Privine nasal spray), oxy-metazoline (Afrin nasal spray).
The results indicated that the potency (pEC50 values) rank order was Dexmedetomidine > Guanabenz > p-aminoclonidine > UK-14304 > Oxymetazoline > Clonidine > Xylometazoline > Guanfacine > Naphazoline
> (-)EPI > [alpha]-methyl-NE > 6-FNE > (-)NE > Deoxy EPI > Dopamine (deoxyNE) > Xylazine > (+)-NE > (-)-Phenylephrine > Isoproterenol.
The sympathomimetic amines include ephedrine and phenylephrine, and the imidazolines include naphazoline
, oxymetazoline, tetrahydrozoline, and xylometazoline.
A safer nasal decongestant is phenylephrine hydrochloride, tetrahydrozoline hydrochloride, naphazoline
hydrochloride, oxymetazoline hydrochloride, and xlometazoline hydrochloride.
SUPPLY AND SAFE DELIVERY OF - EYE DROP - NAPHAZOLINE
As noted earlier, any 'red eye' with an inflammatory aetiology (including episcleritis) will likely respond in the short term to being kept adequately lubricated (to offset the effects of persistent lacrimation) and some comfort be realized with the judicious use of a topical ocular decongestant (eg, naphazoline
The OTC product line is made up of Imidazyl, decongestant eye drops containing the active ingredient naphazoline
nitrate and indicated in cases of burning and redness of the eye; Imidazyl Antihistamine, eye drops containing the active ingredient naphazoline
nitrate and thonzylamine chlorohydrate indicated in allergic and inflammatory states of the eye and conjunctivitis; and Herbe eye drops containing bezalkonium chloride as its active ingredient for cases of mild irritation.