What is the prognostic value of myocardial perfusion imaging
using rubidium-82 positron emission tomography?
It has been used frequently as one of the main stress protocols and the best physiological stress technique for scintigraphic assessment of ischemia and myocardial perfusion imaging
Myocardial perfusion imaging
(MPI) is a non-invasive test that utilizes a small amount of radioactive material (radiopharmaceutical) injected into the body to depict the distribution of blood flow to the heart.
The findings demonstrated PET myocardial perfusion imaging
with flurpiridaz F 18 provided superior image quality, diagnostic certainty and diagnostic performance for detecting CAD compared to single photon emission computed tomography (SPECT) myocardial perfusion imaging
(MPI), the current standard for the non-invasive detection of CAD.
The study was a follow-up to the Detection of Ischemia in Asymptomatic Diabetics (DIAD)-1 study, which documented a 22% prevalence of silent myocardial ischemia during adenosine stress testing with sestamibi single-photon emission computed tomography myocardial perfusion imaging
In the Phase 2 trial, 143 patients from 21 centers underwent rest and stress PET and SPECT myocardial perfusion imaging
and were evaluated for safety.
Diagnostic accuracy of rubidium-82 myocardial perfusion imaging
with hybrid positron emission tomography/ computed tomography in the detection of coronary artery disease.
The study was presented in a poster at the meeting, and included 302 patients referred for clinically indicated rest-stress myocardial perfusion imaging
(MPI) with technetium 99m sestamibi.
Phase 2 safety and clinical comparison of flurpiridaz F 18 injection PET and SPECT myocardial perfusion imaging
for diagnosis of coronary artery disease
SPECT myocardial perfusion imaging
can be used to quantitatively evaluate the therapeutic efficacy of Generx by measuring improved myocardial blood flow under stress; it is also a key prognostic indicator of future cardiovascular events.
Some data regarding 3T myocardial perfusion imaging
are currently available, evaluating perfusion imaging at 3T compared with 1.
The complaint of shortness of breath in a diabetic patient without known coronary artery disease is a red flag that should trigger an extensive cardiovascular work-up including stress myocardial perfusion imaging
The primary objective of the study will be to assess the diagnostic efficacy (sensitivity and specificity) of flurpiridaz F-18 injection PET myocardial perfusion imaging
(MPI), compared with SPECT MPI in the detection of significant coronary artery disease.
Mahmarian's research addresses how to tailor therapy, reduce healthcare costs, and improve treatment of heart disease using nuclear imaging, including myocardial perfusion imaging
, cardiac CT, hybrid imaging, and calcium scoring.
The Company is also advancing its late-stage drug candidate, Stedivaze, a pharmacologic stress agent in Phase III development for use during myocardial perfusion imaging