Huntington disease: A case study describing the complexities and nuances of predictive testing of monozygotic
twins discordant for Huntington disease after 7 years.
The effect of training in male prepubertal and pubertal monozygotic
Thus, the hypothesis suggesting that most female monozygotic
twins are likely to be discordant in the differential expression of their X-linked genes remains logical and experimentally supported [Singh et al.
64) Nichols conducted a metaanalysis of the twin literature, and averaged all of the correlations; he found that the DT scores of monozygotic
twins were correlated at .
Leaf Extract Reduces Blood Pressure in Borderline Hypertensive Monozygotic
As shown with our twin pair, monozygotic
twins of patients who present with cardiac disease have a high likelihood of developing similar conditions.
The anti-hypertensive and cholesterol-lowering actions of the Olive leaf extract (EFLA [R]943) were previously demonstrated in a clinical study carried out in 20 monozygotic
adult twin pairs with mild hypertension (systolic BP of 120-160 mm Hg and diastolic BP of 80-95 mm Hg) in Germany (Perrinjaquet-Moccetti et al.
There is a strong genetic tendency, 75 per cent of monozygotic
twins are concordant for the disease, compared to 10 per cent of dizygotic twins; 10 per cent of first degree family relatives of an index patient have celiac disease8.
1-3) Suggestions of a genetic association include studies that have revealed that the concordance of clubfoot is about 33% for monozygotic
twins versus only 3% for dizygotic twins.
4,11) Most recently, the genetic versus environmental contributions in MS were highlighted in a landmark Nature publication that evaluated the genomic epigenomic, and RNA sequences in purified CD4+ T-cells of monozygotic
twins discordant for MS.
In particular, they found that monozygotic
(MZ), or identical twins, showed more problems than their dyzygotic (DZ), or fraternal twin, peers, and the problems experienced by the MZ twins continued over the course of the study.
The risk of disease in siblings of RA patients compared with that of the general population (Xs) is estimated as 2-17 and the concordance rates for monozygotic
twins versus dizygotic twins range between 15% and 3.
By studying both monozygotic
(MZ) and dizygotic (DZ) twin pairs, we were able to control for childhood environment and partially for genetic liability as MZ co-twins share all and DZ co-twins on average half of their segregating genes.
This child was a monozygotic
twin born to healthy nonconsanguineous parents, and his growth and development were within normal limits.