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A drop in systolic blood pressure of 3 mm Hg can decrease stroke mortality by 8% and coronary artery disease by 5%.
Also new is a review of eight trials involving pharmacologic treatment of isolated systolic hypertension (SBP greater than 160 mm Hg with DBP below 95 mm Hg) in adults older than 60 years, in which active treatment reduced the risk of stroke by 30%, coronary heart disease events by 30%, cardiovascular mortality by 18%, and total mortality by 13%.
4 mm Hg when the doses of medications were cut in half.
Achieving a systolic pressure of 120-129 mm Hg was not much more beneficial for patients, however, and more aggressive reductions to 110-119 mm Hg were harmful to some patients, Dr.
The concept of a continuous graded relationship between DBP and cardiovascular risk is supported by a meta-analysis of 14 randomized clinical trials showing that lowering DBP by 6 mm Hg reduced the risk of coronary heart disease by 14% (95% confidence interval [CI], 4%-22%; P<.
To put it into perspective, for every 20/10 mm Hg rise in blood pressure above 115 / 75 mm Hg, there is a doubling in risk of death from cardiovascular problems," he said.
Among LIFE participants with a baseline SBP below 164 mm Hg, achievement of an average on-treatment SBP below 142 mm Hg was associated with a 40% reduction in all-cause mortality more than 4 years of follow-up, compared with those with an achieved SBP of 152 mm Hg or more.
At 1-year follow-up, the average systolic BPs were 138 mm Hg and 127 mm Hg in the higher-and lower-target groups, having fallen from an average of 145 mm Hg and 144 mm Hg, respectively, at baseline.
The crossover study involved 61 postmenopausal women, 49 of whom were normotensive, and 12 with hypertension, defined as an entry systolic blood pressure of at least 140 mm Hg and a diastolic pressure of at least 90 mm Hg.
High blood pressure is defined as systolic (heart-pumping) pressure of at least 140 millimeters of mercury (mm Hg) and diastolic (heart-resting) pressure of at least 90 mm Hg.
ORLANDO -- The paradigm-shifting results from SPRINT showed the added benefit from a new target systolic blood pressure goal of less than 120 mm Hg for many patients with risk factors for cardiovascular disease, but the results did not address the issue of which systolic blood pressure to use to identify patients who have hypertension and require drug intervention.
1 mm Hg and a 28% reduction in the mean number of glaucoma medications used after 36 months of follow-up.
For many years, the approach to the diagnosis of hypertension was straight-forward--multiple blood pressure (BP) measurements [greater than or equal to] 140/90 mm Hg established the diagnosis of hypertension, a disease associated with an increased risk of adverse cardiovascular events, including myocardial infarction and stroke.
After four weeks on the DASH diet, participants had an average 11 mm Hg reduction in their systolic blood pressure, but those who combined the DASH diet with a low-sodium diet had an average reduction of 21 mm Hg.
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