Laboratory investigation of suspected metabolic encephalopathy
Laboratory Sample requirements Rationale investigations Tier 1 Arterial blood gas Capped heparin blood on High anion gap acidosis plus plasma ice, plus 1 ml heparin in OAs, respiratory [Na.
Pathologic findings in a zebu with spongiform encephalopathy, Switzerland, 2004 Site Finding Vertebral column Severe degeneration of intervertebral discs with ankylosing spondylarthrosis Joints of extremities Degenerative joint disease Liver Biliary cysts (affecting 60% of the liver) Kidney Tubular cysts; mild interstitial nephritis with glomerulosclerosis and tubular atrophy Urinary bladder Multiple papillomas Abdominal cavity Multiple foci of fat necrosis Cardiovascular system Mild coronary arteriosclerosis; mild valvular endocardiosis (mitral valve) Mediastinal lymph nodes Focal metastatic neuroendocrine tumor (origin unknown) Central nervous system Spongiform encephalopathy; metabolic encephalopathy
(hepatoencephalopathy) Table 2.
Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy
Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD)--LCAD in infants is typified by failure to thrive, enlarged liver, enlarged heart, metabolic encephalopathy
, and hypotonia.
However, there was sparing of the striatum, cortices, and hippocampus, which is consistent with a toxic metabolic encephalopathy