Currently under development, CyDex's new intravenous formulation of melphalan
(propylene glycol-free) is enabled by CAPTISOL([R]) - the company's proprietary and patented sulfobutylether -cyclodextrin.
followed by ASCT is currently considered the most effective treatment for AL amyloidosis.
A French group randomized 100 patients aged 18 to 70 between the foregoing melphalan
-dexamethasone regimen and high-dose melphalan
with ASCT After a median follow-up of 3 years, median OS was 56.
Twenty-four hours after the melphalan
dose the autologous stem cells are reinfused.
Thal/Dex was associated with an increased response rate before, but not after, therapy with high-dose melphalan
Mrs Doswell, who had bone cancer, visited her consultant, Dr Aboobucker Abdul-Cader at St Cross Hospital in Rugby on June 26, 1997 and was prescribed a course of Melphalan
The initiation of the pivotal trial for our Captisol-enabled, PG-free melphalan
is an important development for this program, and for Ligand," commented Matthew W.
24] They treated an elderly woman with disease of the lower extremity with tumor necrosis factor and melphalan
and reported no evidence of recurrent disease at 2 years of followup.
Bigmar intends to formulate and market a number of generic oncology drugs in IV bags, including, Fluorouracil, Doxorubicin, Methotrexate, Dacarbazine, Carboplatin, Aclarubicin, Ganciclovir, Azathioprine, Cyclophosphamide, Ifosfamide, Melphalan
, Vincristinsulphate, Cisplatin, Amsakrine, Etoposide, Vinblastin and Dactinomycin.
Dr Frederick Roberts, aged 58, prescribed Melphalan
to Mary Doswell without taking notice of textbook warnings, it was claimed.
4-fold greater risk of leukemia, and those treated with "alkylating" chemotherapy drugs such as melphalan
or cyclophosphamide had a 10-fold greater risk.
al, pre-published online April 4, 2012, Zalicus researchers, in collaboration with the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, have discovered that adenosine A2A and beta-2 adrenergic receptor agonists are highly synergistic and selective novel agents that enhance glucocorticoid activity in B-cell malignancies such as multiple myeloma and, importantly, can synergize in combination with current multiple myeloma treatment regimens such as melphalan
, lenalidomide, bortezomib and doxorubicin.
c]ABenefit of bortezomib, in combination with melphalan
and prednisone (VMP), seen across multiple patient subgroups regardless of subsequent extensive therapy
The VISTA trial compared patients taking VELCADE, melphalan
and prednisone, to those treated with just melphalan
SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) today announced data from the Phase II study with its Captisol-enabled([R]), propylene glycol-free (PG-free) melphalan