In our set up the most common cause of megaloblastic anemia
is nutritional deficiency of Vit B-12 and folate.
Diphyllobothrium pacificum infection is seldom associated with megaloblastic anemia
3) Megaloblastic anemia
was the commonest cause of pancytopenia (70.
Patients with a history of other inflammatory or noninflammatory arthritis, megaloblastic anemia
, malignancies, renal disease with severe renal insufficiency, chronic infectious and inflammatory diseases, and other diseases in the stage of decompensation were excluded from the study.
Study of serum vitamin B-12 and folate levels in patients of megaloblastic anemia
in Northern Pakistan.
5%) were Coomb's positive, indicating Immunemediated Hemolytic Anemia as the cause of megaloblastic anemia
in adults and acute leukemia with aplastic/hypoplastic anemia in children were the most common causes (Table 1), as previously reported (3), (4).
Vitamin B12 deficiencies lead to delayed DNA synthesis resulting in megaloblastic anemia
, peripheral neuropathy, and other neurologic signs (4,5).
LDH examined in conjunction with the known normal bilirubin level would further rule out anemia due to accelerated red cell death either in the peripheral blood as in hemolysis or within the marrow where maturation defects result in ineffective erythropoiesis, as in megaloblastic anemia
Chen et al have reported the occurrence of megaloblastic anemia
in a young woman with chronic autoimmune thyroiditis, who has presented with iron deficiency anemia that has been diagnosed initially (15).
Folic acid promotes cellular growth and maturation of red blood cells, and deficiency of folic asid is associated with reduced growth and with megaloblastic anemia
(19), eventhough megaloblastic changes in the bone marrow due to folate deficiency are found in a certain segment of patients receiving AED (2,19).
In reviewing the patient's chart, you quickly noticed the anemic blood values for hemoglobin and hematocrit, but you also noticed the red blood cell indices (MCV and MCH) suggested not the typical iron deficiency anemia (microcytosis), but a megaloblastic anemia
Association between subacute combined degeneration, vitamin B12 deficiency and megaloblastic anemia
If folate deficiency appears, as in megaloblastic anemia
, the etiology may be due to alcohol abuse; alcohol impairs absorption of folic acid (Guralnik et al.
Iron deficiency anemia may exist concurrently with ACD or megaloblastic anemia
in some patients.