During the 30-day treatment period and gestation period (from day zero to day 21) no visible clinical signs of maternal toxicity
, such as weight loss or reduced feed intake, were recorded.
Severe maternal toxicity
can result from anthrax exposure.
Heptachlor and dieldrin administered to pregnant rats, although causing some maternal toxicity
, resulted in increased activity of striatal DAT in offspring exposed during gestational, perinatal, and adolescent periods (Purkerson-Parker et al.
Prior to approval of the monoclonal antibody by the Food and Drug Administration for treating patients with Crohn's disease and rheumatoid arthritis, studies in a mouse model showed no evidence of maternal toxicity
, embryotoxicity, or teratogenicity.
Conventional developmental and reproductive toxicology assays in mice, rats, and rabbits consistently fail to find adverse effects of TCE on fertility or embryonic development aside from embryo- or fetotoxicity associated with maternal toxicity
[Cosby and Dukelow 1992; Dorfmueller et al.
In those studies, exposure to PFOS during pregnancy led to significant physiologic alterations that indicate maternal toxicity
2001) and do not increase until very large doses are used that produce maternal toxicity
These doses bracket the threshold for maternal toxicity
and fetal cholinesterase inhibition.