From the descending aorta, the blood courses its way to the placenta where it participates in gas exchange with maternal circulation
Using 500-nm PS beads, nearly all particles were retained in the maternal circulation
or placental tissue, and the concentration of beads detected in the fetal circulation was 0.
Current potential applications for analysis of fetal cells and of cell-free fetal DNA in maternal circulation
include noninvasive detection of certain paternally inherited genetic traits and noninvasive detection of fetal Rhesus (Rh) D genotype in Rh(D)-sensitized patients.
Many millions of sequencing reads at an appropriate depth of coverage are required to reliably quantify the miniscule increment or decrement in chromosomal dosage in the maternal circulation
due to the fetal aneuploidy, and this has become feasible only with the advent of NGS technology.
The discovery of fetal cfDNA in maternal circulation
during pregnancy raised the possibility of new methods for non-invasive detection of fetal chromosomal abnormalities.
When AFE was first described more than 70 years ago, it was thought to result from amniotic fluid entering the maternal circulation
and obstructing the pulmonary blood flow - thus the name "amniotic fluid embolism.
FCMB was founded in 2005 with the vision of developing the first non-invasive prenatal diagnostics technology platform based on the capture of fetal cells in maternal circulation
The fetal thyroid gland obtains iodide for its own TH synthesis from the maternal circulation
through the placenta.
Assuming a plasma volume of 3850 mL (31), we estimated the amount of fetal DNA present in the maternal circulation
at T1 and T2, and we calculated the amount of fetal DNA cleared from the maternal circulation
during this period by subtracting the amount of fetal DNA at T2 from that at T1 (see Tables 7 and 8 in the online Data Supplement).
Fetal cell-free DIMA may be detected in maternal circulation
Because the amounts in the maternal circulation
are usually very low, any exposure of a nursing infant probably is clinically insignificant.
in the first-trimester human placenta--myth or reality?
By evaluating cfDNA from the fetus found in maternal circulation
, the test can assess the risk of Down syndrome with greater than 99% accuracy and provide fetal sex information.
Placental apoptosis is a naturally occurring process during gestation in both normal and abnormal pregnancies, resulting in fragmented fetal DNA circulating in the maternal circulation
Circulating levels of sFlt-1 are increased in pre-eclampsia and particularly the early onset form of the disease, resulting in reduced levels of free VEGF-A and P1GF in the maternal circulation